BRD-U60236422_WH-4-025_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-U60236422_WH-4-025_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA4 annexin A4
BST2 bone marrow stromal cell antigen 2
C14ORF132 chromosome 14 open reading frame 132
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C4BPA complement component 4 binding protein, alpha
CA11 carbonic anhydrase XI
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAST calpastatin
CD14 CD14 molecule
CD163 CD163 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CTSD cathepsin D
DNM1 dynamin 1
DPYD dihydropyrimidine dehydrogenase
ECH1 enoyl CoA hydratase 1, peroxisomal
ERBB3 erb-b2 receptor tyrosine kinase 3
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSN gelsolin
GSTT1 glutathione S-transferase theta 1
H2AFV H2A histone family, member V
HNMT histamine N-methyltransferase
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IRF9 interferon regulatory factor 9
KYNU kynureninase
LACTB2 lactamase, beta 2
LIMCH1 LIM and calponin homology domains 1
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MFAP2 microfibrillar-associated protein 2
MTSS1 metastasis suppressor 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PRKCQ protein kinase C, theta
PRTN3 proteinase 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SNN stannin
TCEA2 transcription elongation factor A (SII), 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADM adrenomedullin
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMD1 adenosylmethionine decarboxylase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAR3 breast cancer anti-estrogen resistance 3
BDNF brain-derived neurotrophic factor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALML5 calmodulin-like 5
CCND1 cyclin D1
CLDN8 claudin 8
CORO1C coronin, actin binding protein, 1C
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EDN1 endothelin 1
EGF epidermal growth factor
EIF5A eukaryotic translation initiation factor 5A
ELOVL1 ELOVL fatty acid elongase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLIPR1 GLI pathogenesis-related 1
GRPEL1 GrpE-like 1, mitochondrial (E. coli)
HBEGF heparin-binding EGF-like growth factor
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGB1BP1 integrin beta 1 binding protein 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LDLR low density lipoprotein receptor
MAPK13 mitogen-activated protein kinase 13
MOK MOK protein kinase
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NRG1 neuregulin 1
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PWP1 PWP1 homolog (S. cerevisiae)
PYCR1 pyrroline-5-carboxylate reductase 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
STK10 serine/threonine kinase 10
STK17A serine/threonine kinase 17a
STK26 serine/threonine protein kinase 26
TBC1D4 TBC1 domain family, member 4
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TM4SF1 transmembrane 4 L six family member 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSPAN5 tetraspanin 5
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase