BRD-U51951544_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

294 genes differentially expressed following the BRD-U51951544_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD17A abhydrolase domain containing 17A
ACPP acid phosphatase, prostate
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADAM10 ADAM metallopeptidase domain 10
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANOS1 anosmin 1
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ARL4C ADP-ribosylation factor-like 4C
BSG basigin (Ok blood group)
CALD1 caldesmon 1
CD36 CD36 molecule (thrombospondin receptor)
CFD complement factor D (adipsin)
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
COPA coatomer protein complex, subunit alpha
CRELD2 cysteine-rich with EGF-like domains 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
ERAP1 endoplasmic reticulum aminopeptidase 1
EREG epiregulin
FBN1 fibrillin 1
FN1 fibronectin 1
FST follistatin
GBP1 guanylate binding protein 1, interferon-inducible
GLO1 glyoxalase I
GLUD2 glutamate dehydrogenase 2
GPM6A glycoprotein M6A
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-C major histocompatibility complex, class I, C
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
LUM lumican
MAOA monoamine oxidase A
MAPK1 mitogen-activated protein kinase 1
MDFIC MyoD family inhibitor domain containing
MMP11 matrix metallopeptidase 11
MSN moesin
MUC16 mucin 16, cell surface associated
NLRP2 NLR family, pyrin domain containing 2
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OLFML2A olfactomedin-like 2A
P3H2 prolyl 3-hydroxylase 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDIA3 protein disulfide isomerase family A, member 3
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRAME preferentially expressed antigen in melanoma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCI protein kinase C, iota
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SH3BGR SH3 domain binding glutamate-rich protein
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORD sorbitol dehydrogenase
SPAG16 sperm associated antigen 16
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SST somatostatin
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
TTC3 tetratricopeptide repeat domain 3
UNC13B unc-13 homolog B (C. elegans)
VCAN versican
VIM vimentin
ZFPM2 zinc finger protein, FOG family member 2
ZNF532 zinc finger protein 532

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL4A ADP-ribosylation factor-like 4A
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ASF1A anti-silencing function 1A histone chaperone
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AXIN1 axin 1
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPF2 D4, zinc and double PHD fingers family 2
E2F6 E2F transcription factor 6
EIF4B eukaryotic translation initiation factor 4B
ELF1 E74-like factor 1 (ets domain transcription factor)
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FAM208B family with sequence similarity 208, member B
FAM46C family with sequence similarity 46, member C
FHL2 four and a half LIM domains 2
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN2 gem (nuclear organelle) associated protein 2
GEMIN4 gem (nuclear organelle) associated protein 4
GGNBP2 gametogenetin binding protein 2
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HSPA14 heat shock 70kDa protein 14
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KIN Kin17 DNA and RNA binding protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP2K3 mitogen-activated protein kinase kinase 3
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MKI67 marker of proliferation Ki-67
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PELO pelota homolog (Drosophila)
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPAP2B phosphatidic acid phosphatase type 2B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PSPC1 paraspeckle component 1
PTRH2 peptidyl-tRNA hydrolase 2
RABIF RAB interacting factor
RAE1 ribonucleic acid export 1
RAP2B RAP2B, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RIOK2 RIO kinase 2
RNF113A ring finger protein 113A
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SEPHS1 selenophosphate synthetase 1
SETD5 SET domain containing 5
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX2 T-box 2
TEX10 testis expressed 10
TFF1 trefoil factor 1
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNPO1 transportin 1
TRAF4 TNF receptor-associated factor 4
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UMPS uridine monophosphate synthetase
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VCPKMT valosin containing protein lysine (K) methyltransferase
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB1 zinc finger and BTB domain containing 1
ZBTB24 zinc finger and BTB domain containing 24
ZC3H4 zinc finger CCCH-type containing 4
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2
ZNF443 zinc finger protein 443