BRD-U51951544_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-U51951544_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BSG basigin (Ok blood group)
CCND2 cyclin D2
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CRP C-reactive protein, pentraxin-related
CYBRD1 cytochrome b reductase 1
DCN decorin
EIF5A eukaryotic translation initiation factor 5A
FABP1 fatty acid binding protein 1, liver
FBN2 fibrillin 2
FGG fibrinogen gamma chain
GAS6 growth arrest-specific 6
GPM6A glycoprotein M6A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
PBLD phenazine biosynthesis-like protein domain containing
PRAME preferentially expressed antigen in melanoma
QPRT quinolinate phosphoribosyltransferase
SLC26A2 solute carrier family 26 (anion exchanger), member 2
TCL1A T-cell leukemia/lymphoma 1A
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
ZMYM2 zinc finger, MYM-type 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADM adrenomedullin
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM1 absent in melanoma 1
AMOTL2 angiomotin like 2
AQP3 aquaporin 3 (Gill blood group)
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AVPI1 arginine vasopressin-induced 1
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL10 B-cell CLL/lymphoma 10
BIRC2 baculoviral IAP repeat containing 2
BLCAP bladder cancer associated protein
BMP4 bone morphogenetic protein 4
CCNA2 cyclin A2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CHERP calcium homeostasis endoplasmic reticulum protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
EIF4B eukaryotic translation initiation factor 4B
EXOSC4 exosome component 4
FBXO28 F-box protein 28
FEM1B fem-1 homolog b (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GCH1 GTP cyclohydrolase 1
GEMIN4 gem (nuclear organelle) associated protein 4
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
INTS5 integrator complex subunit 5
IRF2 interferon regulatory factor 2
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
METTL18 methyltransferase like 18
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMP7 matrix metallopeptidase 7
MRFAP1L1 Morf4 family associated protein 1-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NPAS2 neuronal PAS domain protein 2
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R10 protein phosphatase 1, regulatory subunit 10
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
RAB14 RAB14, member RAS oncogene family
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
S100P S100 calcium binding protein P
SASH1 SAM and SH3 domain containing 1
SAV1 salvador family WW domain containing protein 1
SCAF8 SR-related CTD-associated factor 8
SCML1 sex comb on midleg-like 1 (Drosophila)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIM29 tripartite motif containing 29
TRIP6 thyroid hormone receptor interactor 6
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UMPS uridine monophosphate synthetase
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2