BRD-U51024685_HG-6-64-01_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-U51024685_HG-6-64-01_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ADGRG2 adhesion G protein-coupled receptor G2
AIF1 allograft inflammatory factor 1
AKR1C3 aldo-keto reductase family 1, member C3
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANXA4 annexin A4
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
C1R complement component 1, r subcomponent
CALHM2 calcium homeostasis modulator 2
CCND2 cyclin D2
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC5 chloride intracellular channel 5
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CREB1 cAMP responsive element binding protein 1
CSF1R colony stimulating factor 1 receptor
CTBP2 C-terminal binding protein 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
GAS1 growth arrest-specific 1
GHR growth hormone receptor
GLS glutaminase
GPNMB glycoprotein (transmembrane) nmb
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
LDLR low density lipoprotein receptor
MAN1A1 mannosidase, alpha, class 1A, member 1
MMP7 matrix metallopeptidase 7
MN1 meningioma (disrupted in balanced translocation) 1
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
N4BP2L1 NEDD4 binding protein 2-like 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUPR1 nuclear protein, transcriptional regulator, 1
NXN nucleoredoxin
OBSL1 obscurin-like 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRKCQ protein kinase C, theta
PSAT1 phosphoserine aminotransferase 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNF130 ring finger protein 130
RPL31 ribosomal protein L31
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGCE sarcoglycan, epsilon
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TAC1 tachykinin, precursor 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TNS3 tensin 3
TPST2 tyrosylprotein sulfotransferase 2
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
XPOT exportin, tRNA
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AREG amphiregulin
ASPH aspartate beta-hydroxylase
BDNF brain-derived neurotrophic factor
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CENPU centromere protein U
CKAP4 cytoskeleton-associated protein 4
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DDAH1 dimethylarginine dimethylaminohydrolase 1
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDN1 endothelin 1
EGR3 early growth response 3
EPHA2 EPH receptor A2
ERAP2 endoplasmic reticulum aminopeptidase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNAS GNAS complex locus
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGA1 high mobility group AT-hook 1
IER3 immediate early response 3
IFRD2 interferon-related developmental regulator 2
JUN jun proto-oncogene
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MYCBP MYC binding protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NUP98 nucleoporin 98kDa
PCNA proliferating cell nuclear antigen
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PSMC3IP PSMC3 interacting protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100B S100 calcium binding protein B
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SOX9 SRY (sex determining region Y)-box 9
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TRIP13 thyroid hormone receptor interactor 13
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGDH UDP-glucose 6-dehydrogenase
WSB2 WD repeat and SOCS box containing 2
ZWINT ZW10 interacting kinetochore protein