BRD-U51024685_HG-6-64-01_HME1_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-U51024685_HG-6-64-01_HME1_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTN1 actinin, alpha 1
ADAM9 ADAM metallopeptidase domain 9
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEMIP cell migration inducing protein, hyaluronan binding
CLDN3 claudin 3
CLDN4 claudin 4
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CTSB cathepsin B
CXCR4 chemokine (C-X-C motif) receptor 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
DRAM1 DNA-damage regulated autophagy modulator 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
EMX2 empty spiracles homeobox 2
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FAM171A1 family with sequence similarity 171, member A1
FXYD2 FXYD domain containing ion transport regulator 2
FYN FYN proto-oncogene, Src family tyrosine kinase
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPR137B G protein-coupled receptor 137B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IARS isoleucyl-tRNA synthetase
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGF2R insulin-like growth factor 2 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JAG1 jagged 1
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LITAF lipopolysaccharide-induced TNF factor
MAP1B microtubule-associated protein 1B
MARS methionyl-tRNA synthetase
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO6 myosin VI
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NUPR1 nuclear protein, transcriptional regulator, 1
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF144A ring finger protein 144A
SARS seryl-tRNA synthetase
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC2 stanniocalcin 2
STK39 serine threonine kinase 39
TGFBI transforming growth factor, beta-induced, 68kDa
TM2D1 TM2 domain containing 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BTN3A2 butyrophilin, subfamily 3, member A2
C3 complement component 3
CALR calreticulin
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDKN3 cyclin-dependent kinase inhibitor 3
CGA glycoprotein hormones, alpha polypeptide
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CRELD2 cysteine-rich with EGF-like domains 2
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EBP emopamil binding protein (sterol isomerase)
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GTSE1 G-2 and S-phase expressed 1
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
INSIG1 insulin induced gene 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LIN28A lin-28 homolog A (C. elegans)
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
NNMT nicotinamide N-methyltransferase
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PBX1 pre-B-cell leukemia homeobox 1
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PTTG1 pituitary tumor-transforming 1
QDPR quinoid dihydropteridine reductase
SDF2L1 stromal cell-derived factor 2-like 1
SUB1 SUB1 homolog (S. cerevisiae)
UBE2S ubiquitin-conjugating enzyme E2S
ZNF165 zinc finger protein 165