BRD-U51024685_HG-6-64-01_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-U51024685_HG-6-64-01_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF4 activating transcription factor 4
BASP1 brain abundant, membrane attached signal protein 1
BID BH3 interacting domain death agonist
C5 complement component 5
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CST3 cystatin C
DDIT4 DNA-damage-inducible transcript 4
DST dystonin
EHF ets homologous factor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
GPX2 glutathione peroxidase 2
GSE1 Gse1 coiled-coil protein
GSN gelsolin
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HP haptoglobin
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IRS2 insulin receptor substrate 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO10 myosin X
NDRG2 NDRG family member 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PADI2 peptidyl arginine deiminase, type II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PER1 period circadian clock 1
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
REPIN1 replication initiator 1
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SATB2 SATB homeobox 2
SCARB2 scavenger receptor class B, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TF transferrin
TLE2 transducin-like enhancer of split 2
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
BACE2 beta-site APP-cleaving enzyme 2
BIRC5 baculoviral IAP repeat containing 5
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CD200 CD200 molecule
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A2 collagen, type I, alpha 2
CSRP2 cysteine and glycine-rich protein 2
CYCS cytochrome c, somatic
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNTT DNA nucleotidylexotransferase
EBP emopamil binding protein (sterol isomerase)
FEN1 flap structure-specific endonuclease 1
GNAS GNAS complex locus
H2AFX H2A histone family, member X
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
L1CAM L1 cell adhesion molecule
LAMA3 laminin, alpha 3
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
LYZ lysozyme
MAGEB2 melanoma antigen family B2
NOV nephroblastoma overexpressed
PDZK1 PDZ domain containing 1
PGK1 phosphoglycerate kinase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRK protein tyrosine phosphatase, receptor type, K
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRM2 ribonucleotide reductase M2
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TSPAN7 tetraspanin 7