BRD-U51024685_HG-6-64-01_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-U51024685_HG-6-64-01_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABLIM1 actin binding LIM protein 1
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
C10ORF10 chromosome 10 open reading frame 10
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCPG1 cell cycle progression 1
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHEK2 checkpoint kinase 2
COL3A1 collagen, type III, alpha 1
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSD cathepsin D
CTSK cathepsin K
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DPYSL2 dihydropyrimidinase-like 2
ECH1 enoyl CoA hydratase 1, peroxisomal
ECI1 enoyl-CoA delta isomerase 1
EMX2 empty spiracles homeobox 2
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
G6PD glucose-6-phosphate dehydrogenase
GLTSCR2 glioma tumor suppressor candidate region gene 2
HMGB3 high mobility group box 3
IRS2 insulin receptor substrate 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD12 potassium channel tetramerization domain containing 12
LITAF lipopolysaccharide-induced TNF factor
MAN1C1 mannosidase, alpha, class 1C, member 1
METTL7A methyltransferase like 7A
N4BP2L1 NEDD4 binding protein 2-like 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
NUPR1 nuclear protein, transcriptional regulator, 1
PBLD phenazine biosynthesis-like protein domain containing
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PRELP proline/arginine-rich end leucine-rich repeat protein
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTK2B protein tyrosine kinase 2 beta
PXDN peroxidasin
PYCARD PYD and CARD domain containing
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCAN2 regulator of calcineurin 2
RPL31 ribosomal protein L31
RTN3 reticulon 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPON2 spondin 2, extracellular matrix protein
SSBP2 single-stranded DNA binding protein 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VNN1 vanin 1

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ANGPTL4 angiopoietin-like 4
ANPEP alanyl (membrane) aminopeptidase
ASPH aspartate beta-hydroxylase
BAG2 BCL2-associated athanogene 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCND1 cyclin D1
CCR7 chemokine (C-C motif) receptor 7
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDK6 cyclin-dependent kinase 6
CFLAR CASP8 and FADD-like apoptosis regulator
CHSY1 chondroitin sulfate synthase 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DHRS2 dehydrogenase/reductase (SDR family) member 2
EDN1 endothelin 1
EIF5A eukaryotic translation initiation factor 5A
EREG epiregulin
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GTPBP4 GTP binding protein 4
HBEGF heparin-binding EGF-like growth factor
IER3 immediate early response 3
IL6 interleukin 6
INHBB inhibin, beta B
ITGAV integrin, alpha V
LRRC17 leucine rich repeat containing 17
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MCAM melanoma cell adhesion molecule
MCFD2 multiple coagulation factor deficiency 2
MIR22HG MIR22 host gene
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MOK MOK protein kinase
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDLIM4 PDZ and LIM domain 4
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PRKCH protein kinase C, eta
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PUS7 pseudouridylate synthase 7 (putative)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SACS sacsin molecular chaperone
SDC2 syndecan 2
SEC61G Sec61 gamma subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPHK1 sphingosine kinase 1
SRGN serglycin
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
TFB2M transcription factor B2, mitochondrial
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A