BRD-U51024685_HG-6-64-01_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-U51024685_HG-6-64-01_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACTC1 actin, alpha, cardiac muscle 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BAMBI BMP and activin membrane-bound inhibitor
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COBL cordon-bleu WH2 repeat protein
COMT catechol-O-methyltransferase
CRYAB crystallin, alpha B
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
EGF epidermal growth factor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
FAM129A family with sequence similarity 129, member A
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GFOD1 glucose-fructose oxidoreductase domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IARS isoleucyl-tRNA synthetase
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
MARS methionyl-tRNA synthetase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
OXTR oxytocin receptor
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PHGDH phosphoglycerate dehydrogenase
PSAT1 phosphoserine aminotransferase 1
PXDN peroxidasin
PYCR1 pyrroline-5-carboxylate reductase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TMEM5 transmembrane protein 5
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADAM28 ADAM metallopeptidase domain 28
ALDOC aldolase C, fructose-bisphosphate
ARL4C ADP-ribosylation factor-like 4C
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHN1 chimerin 1
CLEC2B C-type lectin domain family 2, member B
COL13A1 collagen, type XIII, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DSC3 desmocollin 3
EMP1 epithelial membrane protein 1
EVI2A ecotropic viral integration site 2A
FAM162A family with sequence similarity 162, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GEM GTP binding protein overexpressed in skeletal muscle
HIST1H1C histone cluster 1, H1c
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INSIG1 insulin induced gene 1
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LAMP5 lysosomal-associated membrane protein family, member 5
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGED1 melanoma antigen family D1
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMO1 methylsterol monooxygenase 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NDRG1 N-myc downstream regulated 1
NLRP2 NLR family, pyrin domain containing 2
NT5DC2 5'-nucleotidase domain containing 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEC plectin
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRDX4 peroxiredoxin 4
RRBP1 ribosome binding protein 1
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SPAG4 sperm associated antigen 4
SPON1 spondin 1, extracellular matrix protein
SPRR1B small proline-rich protein 1B
SRGN serglycin
SRSF6 serine/arginine-rich splicing factor 6
STX1A syntaxin 1A (brain)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A