BRD-U51024685_HG-6-64-01_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

338 genes differentially expressed following the BRD-U51024685_HG-6-64-01_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ADCY9 adenylate cyclase 9
AHNAK2 AHNAK nucleoprotein 2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA4 annexin A4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF159 chromosome 14 open reading frame 159
C1RL complement component 1, r subcomponent-like
C6ORF48 chromosome 6 open reading frame 48
CAMLG calcium modulating ligand
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFB complement factor B
CFD complement factor D (adipsin)
COL11A1 collagen, type XI, alpha 1
COLEC12 collectin sub-family member 12
COPA coatomer protein complex, subunit alpha
CRABP2 cellular retinoic acid binding protein 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTSD cathepsin D
CTSK cathepsin K
DDIT3 DNA-damage-inducible transcript 3
DIAPH2 diaphanous-related formin 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EFNA1 ephrin-A1
EPHA3 EPH receptor A3
EPS8 epidermal growth factor receptor pathway substrate 8
F11R F11 receptor
FAM63A family with sequence similarity 63, member A
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GABARAP GABA(A) receptor-associated protein
GBP2 guanylate binding protein 2, interferon-inducible
GLTSCR2 glioma tumor suppressor candidate region gene 2
GSDMB gasdermin B
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS1BP3 HCLS1 binding protein 3
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LETMD1 LETM1 domain containing 1
LOX lysyl oxidase
LTBP3 latent transforming growth factor beta binding protein 3
MAGEA3 melanoma antigen family A3
MAGED2 melanoma antigen family D2
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MTMR11 myotubularin related protein 11
MTSS1 metastasis suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYO1D myosin ID
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFE2L1 nuclear factor, erythroid 2-like 1
NNT nicotinamide nucleotide transhydrogenase
NOV nephroblastoma overexpressed
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
OBSL1 obscurin-like 1
ORAI3 ORAI calcium release-activated calcium modulator 3
OSBPL1A oxysterol binding protein-like 1A
PAM peptidylglycine alpha-amidating monooxygenase
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PGAP3 post-GPI attachment to proteins 3
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLA2G16 phospholipase A2, group XVI
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PYCARD PYD and CARD domain containing
RABAC1 Rab acceptor 1 (prenylated)
RHOQ ras homolog family member Q
RPL31 ribosomal protein L31
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SARS seryl-tRNA synthetase
SELENBP1 selenium binding protein 1
SERINC3 serine incorporator 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFXN3 sideroflexin 3
SIDT2 SID1 transmembrane family, member 2
SLC22A18 solute carrier family 22, member 18
SLC35E2B solute carrier family 35, member E2B
SPATA20 spermatogenesis associated 20
SPP1 secreted phosphoprotein 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNGR3 synaptogyrin 3
TCF25 transcription factor 25 (basic helix-loop-helix)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS3 thrombospondin 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TPPP3 tubulin polymerization-promoting protein family member 3
TRAPPC6A trafficking protein particle complex 6A
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WARS tryptophanyl-tRNA synthetase
WDR13 WD repeat domain 13
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADAM19 ADAM metallopeptidase domain 19
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX15B arachidonate 15-lipoxygenase, type B
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
EFHD2 EF-hand domain family, member D2
EIF4E eukaryotic translation initiation factor 4E
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EXOSC9 exosome component 9
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HBD hemoglobin, delta
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HN1 hematological and neurological expressed 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
JAG1 jagged 1
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LMNB2 lamin B2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MTERF3 mitochondrial transcription termination factor 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NLRP2 NLR family, pyrin domain containing 2
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
ORC6 origin recognition complex, subunit 6
OSBPL3 oxysterol binding protein-like 3
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PRC1 protein regulator of cytokinesis 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAD51 RAD51 recombinase
RAD51AP1 RAD51 associated protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RANBP1 RAN binding protein 1
RBM14 RNA binding motif protein 14
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFWD3 ring finger and WD repeat domain 3
RGS2 regulator of G-protein signaling 2
RPA2 replication protein A2, 32kDa
RPA3 replication protein A3, 14kDa
RPIA ribose 5-phosphate isomerase A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPHS1 selenophosphate synthetase 1
SFPQ splicing factor proline/glutamine-rich
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPG small nuclear ribonucleoprotein polypeptide G
SPARCL1 SPARC-like 1 (hevin)
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRGN serglycin
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCL1A T-cell leukemia/lymphoma 1A
TFRC transferrin receptor
TIMELESS timeless circadian clock
TMPO thymopoietin
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRIP13 thyroid hormone receptor interactor 13
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2N ubiquitin-conjugating enzyme E2N
VRK1 vaccinia related kinase 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZWINT ZW10 interacting kinetochore protein