BRD-U44618005_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-U44618005_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
ARL4C ADP-ribosylation factor-like 4C
ASS1 argininosuccinate synthase 1
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CHMP1B charged multivesicular body protein 1B
CST3 cystatin C
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DUSP4 dual specificity phosphatase 4
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP7 fatty acid binding protein 7, brain
FADS2 fatty acid desaturase 2
FAM117A family with sequence similarity 117, member A
FGFBP1 fibroblast growth factor binding protein 1
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BH histone cluster 1, H2bh
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MEIS1 Meis homeobox 1
MOXD1 monooxygenase, DBH-like 1
MSMO1 methylsterol monooxygenase 1
PDIA3 protein disulfide isomerase family A, member 3
PHYH phytanoyl-CoA 2-hydroxylase
RAP1GAP RAP1 GTPase activating protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SQLE squalene epoxidase
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TSC22D3 TSC22 domain family, member 3
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
CCND1 cyclin D1
EGFR epidermal growth factor receptor
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FLNB filamin B, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
PALLD palladin, cytoskeletal associated protein
PTPRO protein tyrosine phosphatase, receptor type, O
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TRA2A transformer 2 alpha homolog (Drosophila)
UGDH UDP-glucose 6-dehydrogenase