BRD-U44618005_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-U44618005_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD6 abhydrolase domain containing 6
AKR1C3 aldo-keto reductase family 1, member C3
ASS1 argininosuccinate synthase 1
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CANX calnexin
CCNG1 cyclin G1
CCNG2 cyclin G2
CD47 CD47 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CLCA2 chloride channel accessory 2
COL15A1 collagen, type XV, alpha 1
CRISP3 cysteine-rich secretory protein 3
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
FAM117A family with sequence similarity 117, member A
G6PD glucose-6-phosphate dehydrogenase
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HBP1 HMG-box transcription factor 1
HLTF helicase-like transcription factor
HOXA5 homeobox A5
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
IVNS1ABP influenza virus NS1A binding protein
LAMP2 lysosomal-associated membrane protein 2
LEPR leptin receptor
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAX8 paired box 8
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1 PDZ domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRTN3 proteinase 3
RBPMS RNA binding protein with multiple splicing
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RNF130 ring finger protein 130
RPL37A ribosomal protein L37a
RRAGD Ras-related GTP binding D
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERINC1 serine incorporator 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SRGN serglycin
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TOB1 transducer of ERBB2, 1
TRIM29 tripartite motif containing 29
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARPC5L actin related protein 2/3 complex, subunit 5-like
BANK1 B-cell scaffold protein with ankyrin repeats 1
BDNF brain-derived neurotrophic factor
CALB1 calbindin 1, 28kDa
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBFB core-binding factor, beta subunit
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CXCL14 chemokine (C-X-C motif) ligand 14
CYTH1 cytohesin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DLX2 distal-less homeobox 2
DUSP4 dual specificity phosphatase 4
EFNB2 ephrin-B2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5A eukaryotic translation initiation factor 5A
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA2 EPH receptor A2
ETV5 ets variant 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FGF2 fibroblast growth factor 2 (basic)
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
GADD45B growth arrest and DNA-damage-inducible, beta
HBEGF heparin-binding EGF-like growth factor
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KRT18 keratin 18, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP1B microtubule-associated protein 1B
MAP2K3 mitogen-activated protein kinase kinase 3
MOK MOK protein kinase
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRG1 neuregulin 1
NRIP3 nuclear receptor interacting protein 3
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRNP prion protein
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBP1 retinol binding protein 1, cellular
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMAD7 SMAD family member 7
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORBS3 sorbin and SH3 domain containing 3
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM100 transmembrane protein 100
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase