BRD-U43867373_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-U43867373_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CLIC4 chloride intracellular channel 4
COL1A1 collagen, type I, alpha 1
COLEC12 collectin sub-family member 12
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DMXL2 Dmx-like 2
FN1 fibronectin 1
FNBP1 formin binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
INSIG1 insulin induced gene 1
LUM lumican
MAOA monoamine oxidase A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA3 protein disulfide isomerase family A, member 3
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
RAD23B RAD23 homolog B (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
THBS2 thrombospondin 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ATF5 activating transcription factor 5
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHIC2 cysteine-rich hydrophobic domain 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
FBXO11 F-box protein 11
GRWD1 glutamate-rich WD repeat containing 1
HBEGF heparin-binding EGF-like growth factor
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PALLD palladin, cytoskeletal associated protein
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMAD3 SMAD family member 3