BRD-U43867373_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-U43867373_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACSL1 acyl-CoA synthetase long-chain family member 1
APOD apolipoprotein D
ASPN asporin
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C3 complement component 3
CAST calpastatin
CD163 CD163 molecule
CFB complement factor B
CHGB chromogranin B
CKAP4 cytoskeleton-associated protein 4
CXADR coxsackie virus and adenovirus receptor
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR24 24-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM13A family with sequence similarity 13, member A
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GAGE3 G antigen 3
GNAS GNAS complex locus
GOLGA8B golgin A8 family, member B
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP5 insulin-like growth factor binding protein 5
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100272216 uncharacterized LOC100272216
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA4 melanoma antigen family A4
MAGEA6 melanoma antigen family A6
MAN2A1 mannosidase, alpha, class 2A, member 1
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MNDA myeloid cell nuclear differentiation antigen
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PRAME preferentially expressed antigen in melanoma
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPON2 spondin 2, extracellular matrix protein
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
THY1 Thy-1 cell surface antigen
TMEM110 transmembrane protein 110
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AK4 adenylate kinase 4
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLTB clathrin, light chain B
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HN1 hematological and neurological expressed 1
IFI27 interferon, alpha-inducible protein 27
LAGE3 L antigen family, member 3
LYPLA1 lysophospholipase I
MT1E metallothionein 1E
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RBP1 retinol binding protein 1, cellular
RPIA ribose 5-phosphate isomerase A
RPL27A ribosomal protein L27a
RPS5 ribosomal protein S5
SIVA1 SIVA1, apoptosis-inducing factor
SMAD3 SMAD family member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TEX10 testis expressed 10
TFAM transcription factor A, mitochondrial
TIPIN TIMELESS interacting protein
TSPAN3 tetraspanin 3
UBE2C ubiquitin-conjugating enzyme E2C
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon