BRD-U43867373_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-U43867373_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARMCX3 armadillo repeat containing, X-linked 3
ASRGL1 asparaginase like 1
C10ORF10 chromosome 10 open reading frame 10
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CENPE centromere protein E, 312kDa
CFD complement factor D (adipsin)
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
ERBB3 erb-b2 receptor tyrosine kinase 3
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC2 Niemann-Pick disease, type C2
NRIP1 nuclear receptor interacting protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
RAP1GAP RAP1 GTPase activating protein
RBM47 RNA binding motif protein 47
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
UBE2B ubiquitin-conjugating enzyme E2B
VAT1 vesicle amine transport 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
BAG2 BCL2-associated athanogene 2
BOP1 block of proliferation 1
C10ORF2 chromosome 10 open reading frame 2
CDC25A cell division cycle 25A
COTL1 coactosin-like F-actin binding protein 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPH2 DPH2 homolog (S. cerevisiae)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
EGR2 early growth response 2
EGR3 early growth response 3
EPHA2 EPH receptor A2
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FJX1 four jointed box 1 (Drosophila)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRWD1 glutamate-rich WD repeat containing 1
HBEGF heparin-binding EGF-like growth factor
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LIF leukemia inhibitory factor
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NELL2 NEL-like 2 (chicken)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NR4A2 nuclear receptor subfamily 4, group A, member 2
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRR7 proline rich 7 (synaptic)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PUS7 pseudouridylate synthase 7 (putative)
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SEH1L SEH1-like (S. cerevisiae)
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
TFF1 trefoil factor 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB2 tribbles pseudokinase 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UCK2 uridine-cytidine kinase 2
WDR3 WD repeat domain 3
WDR43 WD repeat domain 43