BRD-U41416256_THZ-2-98-01_HEPG2_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-U41416256_THZ-2-98-01_HEPG2_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGAP6 Rho GTPase activating protein 6
BCL6 B-cell CLL/lymphoma 6
CCND2 cyclin D2
CD163 CD163 molecule
CLEC7A C-type lectin domain family 7, member A
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNM1L dynamin 1-like
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
F13A1 coagulation factor XIII, A1 polypeptide
FCN1 ficolin (collagen/fibrinogen domain containing) 1
GREB1 growth regulation by estrogen in breast cancer 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ISG15 ISG15 ubiquitin-like modifier
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MKNK1 MAP kinase interacting serine/threonine kinase 1
MX1 MX dynamin-like GTPase 1
MYH11 myosin, heavy chain 11, smooth muscle
OLFM4 olfactomedin 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNMAL1 paraneoplastic Ma antigen family-like 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SPON2 spondin 2, extracellular matrix protein
TBX2 T-box 2
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein
VSIG4 V-set and immunoglobulin domain containing 4
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
ASPH aspartate beta-hydroxylase
BGN biglycan
CCL20 chemokine (C-C motif) ligand 20
CD200 CD200 molecule
CD24 CD24 molecule
CETN2 centrin, EF-hand protein, 2
COL3A1 collagen, type III, alpha 1
CRIP2 cysteine-rich protein 2
CTGF connective tissue growth factor
FGB fibrinogen beta chain
FMR1 fragile X mental retardation 1
FOLR1 folate receptor 1 (adult)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAPTM4B lysosomal protein transmembrane 4 beta
PFN2 profilin 2
POSTN periostin, osteoblast specific factor
RBP4 retinol binding protein 4, plasma
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNX7 sorting nexin 7
SPEN spen family transcriptional repressor
STK10 serine/threonine kinase 10
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TSPAN12 tetraspanin 12
TSPAN3 tetraspanin 3