BRD-U41416256_THZ-2-98-01_A549_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-U41416256_THZ-2-98-01_A549_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
AMIGO2 adhesion molecule with Ig-like domain 2
C7 complement component 7
CD44 CD44 molecule (Indian blood group)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFD complement factor D (adipsin)
CNN1 calponin 1, basic, smooth muscle
CNOT4 CCR4-NOT transcription complex, subunit 4
CPM carboxypeptidase M
CX3CL1 chemokine (C-X3-C motif) ligand 1
DCLK1 doublecortin-like kinase 1
FRZB frizzled-related protein
GREM1 gremlin 1, DAN family BMP antagonist
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRT14 keratin 14, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
MCAM melanoma cell adhesion molecule
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MSN moesin
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NES nestin
NPY neuropeptide Y
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PDLIM5 PDZ and LIM domain 5
PLK1 polo-like kinase 1
PLN phospholamban
PMP22 peripheral myelin protein 22
RBM34 RNA binding motif protein 34
RGS5 regulator of G-protein signaling 5
RIMS3 regulating synaptic membrane exocytosis 3
SFRP1 secreted frizzled-related protein 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SORBS2 sorbin and SH3 domain containing 2
SYNM synemin, intermediate filament protein
TAGLN transgelin
TCF4 transcription factor 4
TGFBI transforming growth factor, beta-induced, 68kDa
TLE4 transducin-like enhancer of split 4
TRIM2 tripartite motif containing 2
UGDH UDP-glucose 6-dehydrogenase
VCAN versican
VPREB3 pre-B lymphocyte 3
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADGRG6 adhesion G protein-coupled receptor G6
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
CLIC3 chloride intracellular channel 3
CLU clusterin
DCN decorin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
FAM46A family with sequence similarity 46, member A
FST follistatin
GPR137B G protein-coupled receptor 137B
GSTM3 glutathione S-transferase mu 3 (brain)
HAL histidine ammonia-lyase
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1RN interleukin 1 receptor antagonist
MAPK13 mitogen-activated protein kinase 13
NBPF10 neuroblastoma breakpoint family, member 10
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PRSS21 protease, serine, 21 (testisin)
RAB4A RAB4A, member RAS oncogene family
S100P S100 calcium binding protein P
SELL selectin L
TFF1 trefoil factor 1
TOB1 transducer of ERBB2, 1
VNN1 vanin 1