BRD-U37049823_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-U37049823_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD24 CD24 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CPA3 carboxypeptidase A3 (mast cell)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DHCR7 7-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FASN fatty acid synthase
FCGBP Fc fragment of IgG binding protein
FCMR Fc fragment of IgM receptor
FDFT1 farnesyl-diphosphate farnesyltransferase 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK2 hook microtubule-tethering protein 2
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IFRD1 interferon-related developmental regulator 1
INSIG1 insulin induced gene 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1D myosin ID
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPTX2 neuronal pentraxin II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PHGDH phosphoglycerate dehydrogenase
PLVAP plasmalemma vesicle associated protein
POSTN periostin, osteoblast specific factor
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAP1GAP RAP1 GTPase activating protein
RGS1 regulator of G-protein signaling 1
S100A14 S100 calcium binding protein A14
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SQLE squalene epoxidase
SST somatostatin
SYT1 synaptotagmin I
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VCAN versican
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ARMCX6 armadillo repeat containing, X-linked 6
ATF5 activating transcription factor 5
BCHE butyrylcholinesterase
BLCAP bladder cancer associated protein
CCDC86 coiled-coil domain containing 86
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHPT1 choline phosphotransferase 1
DKC1 dyskeratosis congenita 1, dyskerin
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP10 dual specificity phosphatase 10
FOSL1 FOS-like antigen 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KRT7 keratin 7, type II
LRRN3 leucine rich repeat neuronal 3
MAT2A methionine adenosyltransferase II, alpha
MED21 mediator complex subunit 21
MID1 midline 1
MRPS2 mitochondrial ribosomal protein S2
NOP16 NOP16 nucleolar protein
NOTCH2 notch 2
PPIF peptidylprolyl isomerase F
PRRX1 paired related homeobox 1
PWP1 PWP1 homolog (S. cerevisiae)
RRM2 ribonucleotide reductase M2
SFPQ splicing factor proline/glutamine-rich
SRGN serglycin
TBX2 T-box 2
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TMPRSS2 transmembrane protease, serine 2
TRIAP1 TP53 regulated inhibitor of apoptosis 1
UBE2N ubiquitin-conjugating enzyme E2N