BRD-U37049823_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-U37049823_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C1QB complement component 1, q subcomponent, B chain
CALU calumenin
CD163 CD163 molecule
CREB3L2 cAMP responsive element binding protein 3-like 2
CTSL cathepsin L
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3B fibronectin type III domain containing 3B
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GPNMB glycoprotein (transmembrane) nmb
HDLBP high density lipoprotein binding protein
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INSR insulin receptor
IRS2 insulin receptor substrate 2
KLF6 Kruppel-like factor 6
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MFAP5 microfibrillar associated protein 5
NFIL3 nuclear factor, interleukin 3 regulated
NUCB2 nucleobindin 2
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
RAP1GAP RAP1 GTPase activating protein
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SORBS2 sorbin and SH3 domain containing 2
SQSTM1 sequestosome 1
TGM2 transglutaminase 2
TMEM176B transmembrane protein 176B
TMPRSS3 transmembrane protease, serine 3
TNC tenascin C
TNS1 tensin 1
TSC22D3 TSC22 domain family, member 3
WIPF2 WAS/WASL interacting protein family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ANXA7 annexin A7
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CETN2 centrin, EF-hand protein, 2
CHPT1 choline phosphotransferase 1
COMMD8 COMM domain containing 8
COX7B cytochrome c oxidase subunit VIIb
CRYZ crystallin, zeta (quinone reductase)
CSTA cystatin A (stefin A)
DCK deoxycytidine kinase
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EMP2 epithelial membrane protein 2
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAT1 histone acetyltransferase 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOMER2 homer scaffolding protein 2
HOPX HOP homeobox
KIAA0101 KIAA0101
MRPS11 mitochondrial ribosomal protein S11
MYCBP MYC binding protein
NUP37 nucleoporin 37kDa
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PSIP1 PC4 and SFRS1 interacting protein 1
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD51C RAD51 paralog C
RBBP4 retinoblastoma binding protein 4
S100A7 S100 calcium binding protein A7
SIVA1 SIVA1, apoptosis-inducing factor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
STMN1 stathmin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUBB6 tubulin, beta 6 class V
TXNDC9 thioredoxin domain containing 9
UBE2N ubiquitin-conjugating enzyme E2N
VRK1 vaccinia related kinase 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta