BRD-U33728988_-666_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

405 genes differentially expressed following the BRD-U33728988_-666_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ACKR3 atypical chemokine receptor 3
ACVR1B activin A receptor, type IB
ADCK3 aarF domain containing kinase 3
ADD3 adducin 3 (gamma)
AHNAK2 AHNAK nucleoprotein 2
AKR1C3 aldo-keto reductase family 1, member C3
AMDHD2 amidohydrolase domain containing 2
ANG angiogenin, ribonuclease, RNase A family, 5
ANPEP alanyl (membrane) aminopeptidase
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
ARL8B ADP-ribosylation factor-like 8B
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BANP BTG3 associated nuclear protein
BIRC2 baculoviral IAP repeat containing 2
BMP2 bone morphogenetic protein 2
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCDC93 coiled-coil domain containing 93
CCNL1 cyclin L1
CDC14B cell division cycle 14B
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COBL cordon-bleu WH2 repeat protein
COG4 component of oligomeric golgi complex 4
CREBBP CREB binding protein
CTSL cathepsin L
CXCL14 chemokine (C-X-C motif) ligand 14
DDB2 damage-specific DNA binding protein 2, 48kDa
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDNRB endothelin receptor type B
EFNA1 ephrin-A1
EIF1B eukaryotic translation initiation factor 1B
EIF5 eukaryotic translation initiation factor 5
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EP300 E1A binding protein p300
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM134A family with sequence similarity 134, member A
FEM1B fem-1 homolog b (C. elegans)
FNBP4 formin binding protein 4
FNTA farnesyltransferase, CAAX box, alpha
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALC galactosylceramidase
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GNPDA1 glucosamine-6-phosphate deaminase 1
GOSR1 golgi SNAP receptor complex member 1
GPX2 glutathione peroxidase 2
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFIH1 interferon induced with helicase C domain 1
IFITM1 interferon induced transmembrane protein 1
IL1R2 interleukin 1 receptor, type II
IL6R interleukin 6 receptor
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INSR insulin receptor
IQCG IQ motif containing G
IRS2 insulin receptor substrate 2
IST1 increased sodium tolerance 1 homolog (yeast)
JADE2 jade family PHD finger 2
JMJD1C jumonji domain containing 1C
KAT6A K(lysine) acetyltransferase 6A
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KDM7A lysine (K)-specific demethylase 7A
KIAA0907 KIAA0907
KIDINS220 kinase D-interacting substrate, 220kDa
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
KYNU kynureninase
LEPR leptin receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MED13 mediator complex subunit 13
METTL7A methyltransferase like 7A
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRPS30 mitochondrial ribosomal protein S30
MT1F metallothionein 1F
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NAMPT nicotinamide phosphoribosyltransferase
NBR1 neighbor of BRCA1 gene 1
NCOA2 nuclear receptor coactivator 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
PELI2 pellino E3 ubiquitin protein ligase family member 2
PER2 period circadian clock 2
PER3 period circadian clock 3
PHF3 PHD finger protein 3
PHIP pleckstrin homology domain interacting protein
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLSCR4 phospholipid scramblase 4
PPAP2B phosphatidic acid phosphatase type 2B
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PUM1 pumilio RNA-binding family member 1
RAE1 ribonucleic acid export 1
RB1CC1 RB1-inducible coiled-coil 1
RBBP6 retinoblastoma binding protein 6
RBM15 RNA binding motif protein 15
RBM47 RNA binding motif protein 47
REG1A regenerating islet-derived 1 alpha
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNASE4 ribonuclease, RNase A family, 4
RNMT RNA (guanine-7-) methyltransferase
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRAGC Ras-related GTP binding C
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEC24B SEC24 family member B
SECISBP2L SECIS binding protein 2-like
SENP6 SUMO1/sentrin specific peptidase 6
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SETD2 SET domain containing 2
SIK3 SIK family kinase 3
SIRPA signal-regulatory protein alpha
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRSF7 serine/arginine-rich splicing factor 7
STAG2 stromal antigen 2
STOM stomatin
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D15 TBC1 domain family, member 15
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
TSC1 tuberous sclerosis 1
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UBAP1 ubiquitin associated protein 1
UBE2C ubiquitin-conjugating enzyme E2C
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBXN7 UBX domain protein 7
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
UPP1 uridine phosphorylase 1
WDR19 WD repeat domain 19
WEE1 WEE1 G2 checkpoint kinase
YTHDC1 YTH domain containing 1
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZCCHC14 zinc finger, CCHC domain containing 14
ZCCHC6 zinc finger, CCHC domain containing 6
ZCCHC8 zinc finger, CCHC domain containing 8
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
ZNF24 zinc finger protein 24
ZNF292 zinc finger protein 292
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ACTN2 actinin, alpha 2
ADAM9 ADAM metallopeptidase domain 9
ADGRF5 adhesion G protein-coupled receptor F5
ADGRL2 adhesion G protein-coupled receptor L2
ADSL adenylosuccinate lyase
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
ANXA3 annexin A3
ANXA6 annexin A6
ARG2 arginase 2
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
BCHE butyrylcholinesterase
BGN biglycan
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAPG capping protein (actin filament), gelsolin-like
CAV2 caveolin 2
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CD47 CD47 molecule
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CKAP4 cytoskeleton-associated protein 4
CKM creatine kinase, muscle
CLIC3 chloride intracellular channel 3
CNN3 calponin 3, acidic
CPM carboxypeptidase M
CSRP2 cysteine and glycine-rich protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBN1 drebrin 1
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
FKBP14 FK506 binding protein 14, 22 kDa
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GDE1 glycerophosphodiester phosphodiesterase 1
GLRX glutaredoxin (thioltransferase)
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP5 insulin-like growth factor binding protein 5
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLHL41 kelch-like family member 41
KRT18 keratin 18, type I
KRT19 keratin 19, type I
L1CAM L1 cell adhesion molecule
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LOXL1 lysyl oxidase-like 1
LRRN3 leucine rich repeat neuronal 3
LYZ lysozyme
MAGEH1 melanoma antigen family H1
MALL mal, T-cell differentiation protein-like
MAOB monoamine oxidase B
MCAM melanoma cell adhesion molecule
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXRA7 matrix-remodelling associated 7
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYL1 myosin, light chain 1, alkali; skeletal, fast
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
MYOZ2 myozenin 2
NAP1L1 nucleosome assembly protein 1-like 1
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMU neuromedin U
NNAT neuronatin
NR2F1 nuclear receptor subfamily 2, group F, member 1
NXN nucleoredoxin
PALLD palladin, cytoskeletal associated protein
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE8B phosphodiesterase 8B
PDIA4 protein disulfide isomerase family A, member 4
PDLIM3 PDZ and LIM domain 3
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNP purine nucleoside phosphorylase
PPA1 pyrophosphatase (inorganic) 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRSS23 protease, serine, 23
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RBP4 retinol binding protein 4, plasma
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RHOBTB3 Rho-related BTB domain containing 3
RPN2 ribophorin II
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A11 S100 calcium binding protein A11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC38A10 solute carrier family 38, member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SMYD3 SET and MYND domain containing 3
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STS steroid sulfatase (microsomal), isozyme S
STXBP6 syntaxin binding protein 6 (amisyn)
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TARS threonyl-tRNA synthetase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM100 transmembrane protein 100
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNC tenascin C
TNNC1 troponin C type 1 (slow)
TNNC2 troponin C type 2 (fast)
TNNI1 troponin I type 1 (skeletal, slow)
TNNI2 troponin I type 2 (skeletal, fast)
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
TSPAN13 tetraspanin 13
TTN titin
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TWF2 twinfilin actin binding protein 2
TXNDC15 thioredoxin domain containing 15
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UXS1 UDP-glucuronate decarboxylase 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR61 WD repeat domain 61
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta