BRD-U33728988_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

276 genes differentially expressed following the BRD-U33728988_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
BCL6 B-cell CLL/lymphoma 6
BPTF bromodomain PHD finger transcription factor
BTG1 B-cell translocation gene 1, anti-proliferative
C19ORF54 chromosome 19 open reading frame 54
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFD complement factor D (adipsin)
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COMP cartilage oligomeric matrix protein
CPA3 carboxypeptidase A3 (mast cell)
CRABP1 cellular retinoic acid binding protein 1
CREBBP CREB binding protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CST1 cystatin SN
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP8 dipeptidyl-peptidase 8
DSP desmoplakin
DST dystonin
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM46A family with sequence similarity 46, member A
FAM65B family with sequence similarity 65, member B
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FXR1 fragile X mental retardation, autosomal homolog 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GOLGA8A golgin A8 family, member A
GSE1 Gse1 coiled-coil protein
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA1033 KIAA1033
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KTN1 kinectin 1 (kinesin receptor)
KYNU kynureninase
LETMD1 LETM1 domain containing 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
METTL7A methyltransferase like 7A
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MT2A metallothionein 2A
MVP major vault protein
MYO6 myosin VI
N4BP2L2 NEDD4 binding protein 2-like 2
NEFL neurofilament, light polypeptide
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBX3 pre-B-cell leukemia homeobox 3
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLK2 polo-like kinase 2
PNISR PNN-interacting serine/arginine-rich protein
POSTN periostin, osteoblast specific factor
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSPC1 paraspeckle component 1
RAP1GAP RAP1 GTPase activating protein
RBBP6 retinoblastoma binding protein 6
RFTN1 raftlin, lipid raft linker 1
RIOK3 RIO kinase 3
RPS27L ribosomal protein S27-like
RSL1D1 ribosomal L1 domain containing 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC62 SEC62 homolog (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRRM2 serine/arginine repetitive matrix 2
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNJ2 synaptojanin 2
TBX3 T-box 3
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM87A transmembrane protein 87A
TRIM22 tripartite motif containing 22
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCAN versican
WIPF2 WAS/WASL interacting protein family, member 2
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB16 zinc finger and BTB domain containing 16
ZCCHC6 zinc finger, CCHC domain containing 6
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACOT7 acyl-CoA thioesterase 7
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRA3 adhesion G protein-coupled receptor A3
ADI1 acireductone dioxygenase 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ANPEP alanyl (membrane) aminopeptidase
APOO apolipoprotein O
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
B3GNT1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CBR1 carbonyl reductase 1
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CETN2 centrin, EF-hand protein, 2
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CPOX coproporphyrinogen oxidase
CYCS cytochrome c, somatic
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCTPP1 dCTP pyrophosphatase 1
DEFB1 defensin, beta 1
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
ECI2 enoyl-CoA delta isomerase 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
ENG endoglin
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM57A family with sequence similarity 57, member A
FAR2 fatty acyl CoA reductase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FEN1 flap structure-specific endonuclease 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLO1 glyoxalase I
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPX3 glutathione peroxidase 3
GSTO1 glutathione S-transferase omega 1
HADH hydroxyacyl-CoA dehydrogenase
HOMER2 homer scaffolding protein 2
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IDI1 isopentenyl-diphosphate delta isomerase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA0101 KIAA0101
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LEPROTL1 leptin receptor overlapping transcript-like 1
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MDK midkine (neurite growth-promoting factor 2)
MELK maternal embryonic leucine zipper kinase
MPC2 mitochondrial pyruvate carrier 2
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPR3 natriuretic peptide receptor 3
OAT ornithine aminotransferase
PAK1IP1 PAK1 interacting protein 1
PARP1 poly (ADP-ribose) polymerase 1
PBK PDZ binding kinase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPID peptidylprolyl isomerase D
PRDX4 peroxiredoxin 4
PROM1 prominin 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RANBP1 RAN binding protein 1
RFK riboflavin kinase
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SELT selenoprotein T
SEPHS1 selenophosphate synthetase 1
SEPW1 selenoprotein W, 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORD sorbitol dehydrogenase
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
SUMO3 small ubiquitin-like modifier 3
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIMELESS timeless circadian clock
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TRAPPC3 trafficking protein particle complex 3
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBB tubulin, beta class I
TUBG1 tubulin, gamma 1
TWF2 twinfilin actin binding protein 2
VIM vimentin
VRK1 vaccinia related kinase 1
WDR61 WD repeat domain 61
ZDHHC6 zinc finger, DHHC-type containing 6