BRD-U33728988_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

203 genes differentially expressed following the BRD-U33728988_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
AREG amphiregulin
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
COL10A1 collagen, type X, alpha 1
CTSK cathepsin K
CYLD cylindromatosis (turban tumor syndrome)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
F5 coagulation factor V (proaccelerin, labile factor)
FAM13A family with sequence similarity 13, member A
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GPX1 glutathione peroxidase 1
GSPT2 G1 to S phase transition 2
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IL13RA2 interleukin 13 receptor, alpha 2
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRIP1 nuclear receptor interacting protein 1
NUPL1 nucleoporin like 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SAT1 spermidine/spermine N1-acetyltransferase 1
SDCBP syndecan binding protein (syntenin)
SFRP1 secreted frizzled-related protein 1
SLC38A2 solute carrier family 38, member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TFF1 trefoil factor 1
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D1 TSC22 domain family, member 1
TXNIP thioredoxin interacting protein
VCL vinculin
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
ADGRA3 adhesion G protein-coupled receptor A3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKR1C1 aldo-keto reductase family 1, member C1
ANPEP alanyl (membrane) aminopeptidase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BAG2 BCL2-associated athanogene 2
C11ORF95 chromosome 11 open reading frame 95
C3 complement component 3
CACYBP calcyclin binding protein
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CBS cystathionine-beta-synthase
CBX3 chromobox homolog 3
CCND1 cyclin D1
CD93 CD93 molecule
CERK ceramide kinase
CFB complement factor B
CNN1 calponin 1, basic, smooth muscle
COL18A1 collagen, type XVIII, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DES desmin
ECI2 enoyl-CoA delta isomerase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
FHOD3 formin homology 2 domain containing 3
FKBP9 FK506 binding protein 9, 63 kDa
FNBP1 formin binding protein 1
GAS2L1 growth arrest-specific 2 like 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HCLS1 hematopoietic cell-specific Lyn substrate 1
HSPA1A heat shock 70kDa protein 1A
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0232 KIAA0232
LAPTM4B lysosomal protein transmembrane 4 beta
LIPA lipase A, lysosomal acid, cholesterol esterase
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP1B microtubule-associated protein 1B
MCAM melanoma cell adhesion molecule
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAGA N-acetylgalactosaminidase, alpha-
NID1 nidogen 1
NT5DC2 5'-nucleotidase domain containing 2
PARP1 poly (ADP-ribose) polymerase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEBP1 phosphatidylethanolamine binding protein 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIR pirin (iron-binding nuclear protein)
PKP4 plakophilin 4
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PODXL podocalyxin-like
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGIS prostaglandin I2 (prostacyclin) synthase
PXDN peroxidasin
PXMP2 peroxisomal membrane protein 2, 22kDa
REEP5 receptor accessory protein 5
RPS11 ribosomal protein S11
RXRA retinoid X receptor, alpha
SAC3D1 SAC3 domain containing 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORBS1 sorbin and SH3 domain containing 1
SYNM synemin, intermediate filament protein
TBC1D16 TBC1 domain family, member 16
TBL1X transducin (beta)-like 1X-linked
TFDP1 transcription factor Dp-1
TUBB6 tubulin, beta 6 class V
TXN thioredoxin
TYMS thymidylate synthetase