BRD-U32365159_-666_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-U32365159_-666_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
ATF5 activating transcription factor 5
BLNK B-cell linker
CHI3L2 chitinase 3-like 2
CKAP4 cytoskeleton-associated protein 4
CXCL5 chemokine (C-X-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
EVI2A ecotropic viral integration site 2A
FKBP1B FK506 binding protein 1B, 12.6 kDa
GLRX glutaredoxin (thioltransferase)
GREM1 gremlin 1, DAN family BMP antagonist
HOMER2 homer scaffolding protein 2
ISG20 interferon stimulated exonuclease gene 20kDa
KLF6 Kruppel-like factor 6
LRMP lymphoid-restricted membrane protein
LTF lactotransferrin
MSMB microseminoprotein, beta-
NEU1 sialidase 1 (lysosomal sialidase)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RTN4 reticulon 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
TFF1 trefoil factor 1
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB2A tubulin, beta 2A class IIa
VAT1 vesicle amine transport 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CLU clusterin
COL3A1 collagen, type III, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CXCL14 chemokine (C-X-C motif) ligand 14
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FLRT2 fibronectin leucine rich transmembrane protein 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXA10 homeobox A10
HPRT1 hypoxanthine phosphoribosyltransferase 1
IGFBP7 insulin-like growth factor binding protein 7
KDM5D lysine (K)-specific demethylase 5D
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LIMCH1 LIM and calponin homology domains 1
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MET MET proto-oncogene, receptor tyrosine kinase
MTUS1 microtubule associated tumor suppressor 1
NMU neuromedin U
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
ST7 suppression of tumorigenicity 7
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TSPAN4 tetraspanin 4
UBE2C ubiquitin-conjugating enzyme E2C
ZNF185 zinc finger protein 185 (LIM domain)