BRD-U31801276_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-U31801276_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CCND2 cyclin D2
CD24 CD24 molecule
CRABP2 cellular retinoic acid binding protein 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRISP3 cysteine-rich secretory protein 3
CTSZ cathepsin Z
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
FST follistatin
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GUSBP11 glucuronidase, beta pseudogene 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT4 keratin 4, type II
LDLR low density lipoprotein receptor
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MGLL monoglyceride lipase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPR3 natriuretic peptide receptor 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
POU2AF1 POU class 2 associating factor 1
PSAT1 phosphoserine aminotransferase 1
RALGDS ral guanine nucleotide dissociation stimulator
RANBP9 RAN binding protein 9
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SELENBP1 selenium binding protein 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOX thymocyte selection-associated high mobility group box
TSC22D3 TSC22 domain family, member 3
VCAM1 vascular cell adhesion molecule 1
WARS tryptophanyl-tRNA synthetase
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ARG1 arginase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2A1 BCL2-related protein A1
BCL6 B-cell CLL/lymphoma 6
CCDC86 coiled-coil domain containing 86
CCL19 chemokine (C-C motif) ligand 19
CD44 CD44 molecule (Indian blood group)
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
IER2 immediate early response 2
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
IRS2 insulin receptor substrate 2
LEF1 lymphoid enhancer-binding factor 1
LPXN leupaxin
MAGED1 melanoma antigen family D1
MME membrane metallo-endopeptidase
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM1 neural cell adhesion molecule 1
NPY1R neuropeptide Y receptor Y1
NRN1 neuritin 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMP22 peripheral myelin protein 22
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRR7 proline rich 7 (synaptic)
SAMD4A sterile alpha motif domain containing 4A
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPSAB1 tryptase alpha/beta 1