BRD-U31801276_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

64 genes differentially expressed following the BRD-U31801276_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
APOA1 apolipoprotein A-I
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CCND2 cyclin D2
CD52 CD52 molecule
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DMBT1 deleted in malignant brain tumors 1
FABP1 fatty acid binding protein 1, liver
GARS glycyl-tRNA synthetase
GRB10 growth factor receptor-bound protein 10
GREB1 growth regulation by estrogen in breast cancer 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI27 interferon, alpha-inducible protein 27
IGL immunoglobulin lambda locus
IRF6 interferon regulatory factor 6
JAG1 jagged 1
LMNA lamin A/C
MAGEA3 melanoma antigen family A3
MGP matrix Gla protein
MLPH melanophilin
MX1 MX dynamin-like GTPase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
TFF3 trefoil factor 3 (intestinal)
XBP1 X-box binding protein 1

decreased expression

Symbol Name
BICC1 BicC family RNA binding protein 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHL1 cell adhesion molecule L1-like
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CST7 cystatin F (leukocystatin)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPRC5B G protein-coupled receptor, class C, group 5, member B
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LITAF lipopolysaccharide-induced TNF factor
MFSD10 major facilitator superfamily domain containing 10
PLEK pleckstrin
PRPF4 pre-mRNA processing factor 4
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXDN peroxidasin
RNF167 ring finger protein 167
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SPRY2 sprouty homolog 2 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A