BRD-U29336476_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

176 genes differentially expressed following the BRD-U29336476_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
AHNAK2 AHNAK nucleoprotein 2
AIDA axin interactor, dorsalization associated
ALDOC aldolase C, fructose-bisphosphate
ANOS1 anosmin 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BSG basigin (Ok blood group)
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CLCN3 chloride channel, voltage-sensitive 3
CLIC4 chloride intracellular channel 4
COLEC12 collectin sub-family member 12
COPA coatomer protein complex, subunit alpha
CXADR coxsackie virus and adenovirus receptor
DEGS1 delta(4)-desaturase, sphingolipid 1
DMPK dystrophia myotonica-protein kinase
DSP desmoplakin
EDNRA endothelin receptor type A
ENO2 enolase 2 (gamma, neuronal)
ETHE1 ethylmalonic encephalopathy 1
EZR ezrin
FBXW2 F-box and WD repeat domain containing 2
FLNA filamin A, alpha
FN1 fibronectin 1
FZD5 frizzled class receptor 5
GATA6 GATA binding protein 6
GSTA4 glutathione S-transferase alpha 4
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITGA6 integrin, alpha 6
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDR kinase insert domain receptor
LAMP3 lysosomal-associated membrane protein 3
LGMN legumain
LIPG lipase, endothelial
LRP4 low density lipoprotein receptor-related protein 4
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MMP12 matrix metallopeptidase 12
MSN moesin
NCAM1 neural cell adhesion molecule 1
NEB nebulin
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NLRP2 NLR family, pyrin domain containing 2
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PEG10 paternally expressed 10
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRUNE2 prune homolog 2 (Drosophila)
PTCH1 patched 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RHOA ras homolog family member A
RHOB ras homolog family member B
ROGDI rogdi homolog (Drosophila)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT10 septin 10
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK1 salt-inducible kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TMEM45A transmembrane protein 45A
TPMT thiopurine S-methyltransferase
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TTN titin
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UNC13B unc-13 homolog B (C. elegans)
VAMP3 vesicle-associated membrane protein 3
WNT5A wingless-type MMTV integration site family, member 5A
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ANXA11 annexin A11
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF1 activating transcription factor 1
B3GNT1
BCAS2 breast carcinoma amplified sequence 2
CASP4 caspase 4, apoptosis-related cysteine peptidase
CD58 CD58 molecule
CHMP6 charged multivesicular body protein 6
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYD dihydropyrimidine dehydrogenase
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ESR1 estrogen receptor 1
EXOSC8 exosome component 8
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GTPBP8 GTP-binding protein 8 (putative)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KRT15 keratin 15, type I
KYNU kynureninase
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY75 lymphocyte antigen 75
MED28 mediator complex subunit 28
METTL7A methyltransferase like 7A
N4BP2L2 NEDD4 binding protein 2-like 2
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
PDGFRL platelet-derived growth factor receptor-like
PDS5B PDS5 cohesin associated factor B
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRR7 proline rich 7 (synaptic)
RFC3 replication factor C (activator 1) 3, 38kDa
RHOQ ras homolog family member Q
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SMNDC1 survival motor neuron domain containing 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SRSF1 serine/arginine-rich splicing factor 1
STAMBP STAM binding protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBX2 T-box 2
TGIF2 TGFB-induced factor homeobox 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WDR43 WD repeat domain 43
XBP1 X-box binding protein 1