BRD-U29336476_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-U29336476_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ANKRD10 ankyrin repeat domain 10
AQP3 aquaporin 3 (Gill blood group)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BRD2 bromodomain containing 2
BSG basigin (Ok blood group)
C1QA complement component 1, q subcomponent, A chain
CCL5 chemokine (C-C motif) ligand 5
CD14 CD14 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC7A C-type lectin domain family 7, member A
COL3A1 collagen, type III, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CTH cystathionine gamma-lyase
CXCL10 chemokine (C-X-C motif) ligand 10
DMD dystrophin
DSP desmoplakin
EGR2 early growth response 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FLNA filamin A, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GJA1 gap junction protein, alpha 1, 43kDa
GSDMB gasdermin B
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HOPX HOP homeobox
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
MARCKSL1 MARCKS-like 1
MMP12 matrix metallopeptidase 12
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEB nebulin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOTCH1 notch 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUSAP1 nucleolar and spindle associated protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PTTG1 pituitary tumor-transforming 1
RGS2 regulator of G-protein signaling 2
SCARB2 scavenger receptor class B, member 2
SEPT6 septin 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIK1 salt-inducible kinase 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
STAB1 stabilin 1
TDO2 tryptophan 2,3-dioxygenase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNT1 troponin T type 1 (skeletal, slow)
TTC3 tetratricopeptide repeat domain 3
TTN titin
TXNIP thioredoxin interacting protein
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIRF adipogenesis regulatory factor
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
ARHGAP29 Rho GTPase activating protein 29
AXL AXL receptor tyrosine kinase
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
CAV2 caveolin 2
CCND1 cyclin D1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFD complement factor D (adipsin)
CTBP2 C-terminal binding protein 2
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5A eukaryotic translation initiation factor 5A
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EREG epiregulin
FXYD2 FXYD domain containing ion transport regulator 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HMGA2 high mobility group AT-hook 2
HOMER3 homer scaffolding protein 3
HOXB7 homeobox B7
ICAM2 intercellular adhesion molecule 2
IGF1R insulin-like growth factor 1 receptor
IRS1 insulin receptor substrate 1
JADE2 jade family PHD finger 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LPAR1 lysophosphatidic acid receptor 1
LY6E lymphocyte antigen 6 complex, locus E
MOK MOK protein kinase
MRPL12 mitochondrial ribosomal protein L12
MSLN mesothelin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F6 nuclear receptor subfamily 2, group F, member 6
OGDHL oxoglutarate dehydrogenase-like
PKP4 plakophilin 4
PLA1A phospholipase A1 member A
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
RGS5 regulator of G-protein signaling 5
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TSPYL5 TSPY-like 5
VCAN versican