BRD-U25771771_-666_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-U25771771_-666_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACTA1 actin, alpha 1, skeletal muscle
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
APOD apolipoprotein D
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BHLHE41 basic helix-loop-helix family, member e41
CAPG capping protein (actin filament), gelsolin-like
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CTSA cathepsin A
CTSB cathepsin B
CXCL5 chemokine (C-X-C motif) ligand 5
DHCR7 7-dehydrocholesterol reductase
ERBB2 erb-b2 receptor tyrosine kinase 2
F13A1 coagulation factor XIII, A1 polypeptide
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FTH1 ferritin, heavy polypeptide 1
GBAP1 glucosidase, beta, acid pseudogene 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRN granulin
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFSD1 major facilitator superfamily domain containing 1
MSMO1 methylsterol monooxygenase 1
MT1X metallothionein 1X
MVP major vault protein
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHYH phytanoyl-CoA 2-hydroxylase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRSS8 protease, serine, 8
PTGDS prostaglandin D2 synthase 21kDa (brain)
RRAGC Ras-related GTP binding C
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STATH statherin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TPM2 tropomyosin 2 (beta)
TRIB3 tribbles pseudokinase 3
TRIM22 tripartite motif containing 22
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
ECI2 enoyl-CoA delta isomerase 2
GAL galanin/GMAP prepropeptide
HIST1H2BG histone cluster 1, H2bg
KIF20A kinesin family member 20A
LPL lipoprotein lipase
NCAPH non-SMC condensin I complex, subunit H
PBK PDZ binding kinase
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC2 replication factor C (activator 1) 2, 40kDa
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMC4 structural maintenance of chromosomes 4
SPON1 spondin 1, extracellular matrix protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
UBE2S ubiquitin-conjugating enzyme E2S