BRD-U25771771_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

114 genes differentially expressed following the BRD-U25771771_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
CFD complement factor D (adipsin)
CTSL cathepsin L
CYB5R2 cytochrome b5 reductase 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
EFNA1 ephrin-A1
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FDPS farnesyl diphosphate synthase
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO4 forkhead box O4
GAS6 growth arrest-specific 6
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1A interleukin 1, alpha
INSIG1 insulin induced gene 1
ISG15 ISG15 ubiquitin-like modifier
KLHL24 kelch-like family member 24
KRAS Kirsten rat sarcoma viral oncogene homolog
LDLR low density lipoprotein receptor
MAPT microtubule-associated protein tau
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MYO1D myosin ID
PCP4 Purkinje cell protein 4
PDGFD platelet derived growth factor D
PLLP plasmolipin
PRUNE2 prune homolog 2 (Drosophila)
PYCARD PYD and CARD domain containing
RAP1GAP RAP1 GTPase activating protein
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELE selectin E
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
SULF1 sulfatase 1
THBS2 thrombospondin 2
TMEM176B transmembrane protein 176B
TNS1 tensin 1
TRIM2 tripartite motif containing 2
WDTC1 WD and tetratricopeptide repeats 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
BOP1 block of proliferation 1
C1QBP complement component 1, q subcomponent binding protein
CDC25A cell division cycle 25A
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
DKC1 dyskeratosis congenita 1, dyskerin
DPH2 DPH2 homolog (S. cerevisiae)
EXOSC4 exosome component 4
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM216A family with sequence similarity 216, member A
FAM98A family with sequence similarity 98, member A
FKBP10 FK506 binding protein 10, 65 kDa
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
LTF lactotransferrin
MARCKSL1 MARCKS-like 1
MINA MYC induced nuclear antigen
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM3 nucleophosmin/nucleoplasmin 3
NUP98 nucleoporin 98kDa
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PRMT1 protein arginine methyltransferase 1
PRR7 proline rich 7 (synaptic)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD23B RAD23 homolog B (S. cerevisiae)
RGS2 regulator of G-protein signaling 2
RPIA ribose 5-phosphate isomerase A
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORD sorbitol dehydrogenase
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae)
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TNC tenascin C
UBE2S ubiquitin-conjugating enzyme E2S
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
WDR43 WD repeat domain 43