BRD-U25771771_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-U25771771_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AQP1 aquaporin 1 (Colton blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX1 armadillo repeat containing, X-linked 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCK cholecystokinin
CD24 CD24 molecule
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
COL15A1 collagen, type XV, alpha 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF5A eukaryotic translation initiation factor 5A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGR FGR proto-oncogene, Src family tyrosine kinase
FXYD3 FXYD domain containing ion transport regulator 3
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GCLC glutamate-cysteine ligase, catalytic subunit
HIST3H2A histone cluster 3, H2a
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
IRF1 interferon regulatory factor 1
KRT14 keratin 14, type I
KRT5 keratin 5, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MECOM MDS1 and EVI1 complex locus
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1X metallothionein 1X
NRGN neurogranin (protein kinase C substrate, RC3)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
SC5D sterol-C5-desaturase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TRIM36 tripartite motif containing 36
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WBP5 WW domain binding protein 5
ZFP36 ZFP36 ring finger protein
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ADGRA3 adhesion G protein-coupled receptor A3
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ANXA6 annexin A6
ASCC3 activating signal cointegrator 1 complex subunit 3
AURKA aurora kinase A
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCND1 cyclin D1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CLIC4 chloride intracellular channel 4
COX11 COX11 cytochrome c oxidase copper chaperone
CP ceruloplasmin (ferroxidase)
CTSG cathepsin G
CXCL8 chemokine (C-X-C motif) ligand 8
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP6 dual specificity phosphatase 6
ENOPH1 enolase-phosphatase 1
FAM46A family with sequence similarity 46, member A
FGB fibrinogen beta chain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLB1 galactosidase, beta 1
HLTF helicase-like transcription factor
ITM2A integral membrane protein 2A
KIF20A kinesin family member 20A
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LPL lipoprotein lipase
MACF1 microtubule-actin crosslinking factor 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MALT1 MALT1 paracaspase
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MKI67 marker of proliferation Ki-67
NES nestin
NOLC1 nucleolar and coiled-body phosphoprotein 1
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCA protein kinase C, alpha
PROS1 protein S (alpha)
PUF60 poly-U binding splicing factor 60KDa
RHOBTB3 Rho-related BTB domain containing 3
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSAD1 radical S-adenosyl methionine domain containing 1
SHCBP1 SHC SH2-domain binding protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNIK TRAF2 and NCK interacting kinase
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZBTB20 zinc finger and BTB domain containing 20