BRD-U25771771_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-U25771771_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AEBP1 AE binding protein 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC2B C-type lectin domain family 2, member B
COLEC12 collectin sub-family member 12
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSE cathepsin E
CTSK cathepsin K
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DRAM1 DNA-damage regulated autophagy modulator 1
EDN3 endothelin 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FBP1 fructose-1,6-bisphosphatase 1
FMOD fibromodulin
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
KLF4 Kruppel-like factor 4 (gut)
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MGLL monoglyceride lipase
MGP matrix Gla protein
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1X metallothionein 1X
MTMR11 myotubularin related protein 11
MYH11 myosin, heavy chain 11, smooth muscle
NET1 neuroepithelial cell transforming 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFRL platelet-derived growth factor receptor-like
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHYH phytanoyl-CoA 2-hydroxylase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB29 RAB29, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
SDC4 syndecan 4
SELE selectin E
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQSTM1 sequestosome 1
THBS2 thrombospondin 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TRAF1 TNF receptor-associated factor 1
TRIB3 tribbles pseudokinase 3
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AURKA aurora kinase A
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BIRC5 baculoviral IAP repeat containing 5
CALD1 caldesmon 1
CAV2 caveolin 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
COL4A5 collagen, type IV, alpha 5
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL13 chemokine (C-X-C motif) ligand 13
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM3C family with sequence similarity 3, member C
GCLC glutamate-cysteine ligase, catalytic subunit
GJA1 gap junction protein, alpha 1, 43kDa
GPX1 glutathione peroxidase 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGA6 integrin, alpha 6
KIAA0485 uncharacterized LOC57235
KIF20A kinesin family member 20A
MALT1 MALT1 paracaspase
MEGF9 multiple EGF-like-domains 9
MOK MOK protein kinase
MXRA7 matrix-remodelling associated 7
NPTX2 neuronal pentraxin II
NT5DC2 5'-nucleotidase domain containing 2
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PROM1 prominin 1
PSPH phosphoserine phosphatase
SORD sorbitol dehydrogenase
SPTSSA serine palmitoyltransferase, small subunit A
SSR1 signal sequence receptor, alpha
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TUBA4A tubulin, alpha 4a
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican