BRD-U07805514_saracatinib_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-U07805514_saracatinib_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ATF3 activating transcription factor 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CCND2 cyclin D2
CCR7 chemokine (C-C motif) receptor 7
CD1E CD1e molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CTSD cathepsin D
CXCL14 chemokine (C-X-C motif) ligand 14
DCT dopachrome tautomerase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DEGS1 delta(4)-desaturase, sphingolipid 1
DLC1 DLC1 Rho GTPase activating protein
DPYSL2 dihydropyrimidinase-like 2
HIST1H2BK histone cluster 1, H2bk
IL1R2 interleukin 1 receptor, type II
IL7R interleukin 7 receptor
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JAG1 jagged 1
LEF1 lymphoid enhancer-binding factor 1
LPL lipoprotein lipase
MEIS2 Meis homeobox 2
MGLL monoglyceride lipase
NREP neuronal regeneration related protein
NRP1 neuropilin 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
QPCT glutaminyl-peptide cyclotransferase
RCAN1 regulator of calcineurin 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A7 S100 calcium binding protein A7
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPAG1 sperm associated antigen 1
TGOLN2 trans-golgi network protein 2
TIMP3 TIMP metallopeptidase inhibitor 3
VCAN versican
WASF3 WAS protein family, member 3

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP1 aquaporin 1 (Colton blood group)
CDC42 cell division cycle 42
CHMP6 charged multivesicular body protein 6
COL3A1 collagen, type III, alpha 1
CRLF1 cytokine receptor-like factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALE UDP-galactose-4-epimerase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL17RB interleukin 17 receptor B
KRT18 keratin 18, type I
KRT19 keratin 19, type I
MAOB monoamine oxidase B
MKNK1 MAP kinase interacting serine/threonine kinase 1
MYH11 myosin, heavy chain 11, smooth muscle
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PTGIS prostaglandin I2 (prostacyclin) synthase
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STK26 serine/threonine protein kinase 26
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCEAL4 transcription elongation factor A (SII)-like 4
TMSB15A thymosin beta 15a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDAC1 voltage-dependent anion channel 1
ZDHHC6 zinc finger, DHHC-type containing 6