BRD-U07805514_saracatinib_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-U07805514_saracatinib_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
AGTR1 angiotensin II receptor, type 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
APMAP adipocyte plasma membrane associated protein
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATF3 activating transcription factor 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
BMP4 bone morphogenetic protein 4
CD9 CD9 molecule
COL9A3 collagen, type IX, alpha 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM134B family with sequence similarity 134, member B
FAM171A1 family with sequence similarity 171, member A1
FERMT2 fermitin family member 2
FOSL1 FOS-like antigen 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GLIPR1 GLI pathogenesis-related 1
GLS glutaminase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA1 high mobility group AT-hook 1
HOXC6 homeobox C6
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LAMB1 laminin, beta 1
LAMP5 lysosomal-associated membrane protein family, member 5
LIMA1 LIM domain and actin binding 1
LRRN3 leucine rich repeat neuronal 3
MAP1B microtubule-associated protein 1B
MMP7 matrix metallopeptidase 7
MTUS1 microtubule associated tumor suppressor 1
MX1 MX dynamin-like GTPase 1
MYO6 myosin VI
MYOF myoferlin
NEFL neurofilament, light polypeptide
NPY neuropeptide Y
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDE8B phosphodiesterase 8B
PLAC8 placenta-specific 8
PMP22 peripheral myelin protein 22
PRNP prion protein
PSD3 pleckstrin and Sec7 domain containing 3
PTN pleiotrophin
PTRF polymerase I and transcript release factor
QDPR quinoid dihydropteridine reductase
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SMAGP small cell adhesion glycoprotein
SORBS3 sorbin and SH3 domain containing 3
SPARCL1 SPARC-like 1 (hevin)
SPP1 secreted phosphoprotein 1
SRPX sushi-repeat containing protein, X-linked
STMN2 stathmin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPM4 tropomyosin 4
TSPAN13 tetraspanin 13
TXNRD1 thioredoxin reductase 1
VAT1 vesicle amine transport 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB38 zinc finger and BTB domain containing 38

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ANXA10 annexin A10
ASS1 argininosuccinate synthase 1
BPHL biphenyl hydrolase-like (serine hydrolase)
C5 complement component 5
CBS cystathionine-beta-synthase
CCL4 chemokine (C-C motif) ligand 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREG1 cellular repressor of E1A-stimulated genes 1
DEPTOR DEP domain containing MTOR-interacting protein
DMD dystrophin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC4 exosome component 4
FBXO9 F-box protein 9
FZD5 frizzled class receptor 5
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKV1-5 immunoglobulin kappa variable 1-5
IL32 interleukin 32
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLK12 kallikrein-related peptidase 12
LMO4 LIM domain only 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MCM3 minichromosome maintenance complex component 3
MPO myeloperoxidase
MSH6 mutS homolog 6
MSMO1 methylsterol monooxygenase 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NFE2 nuclear factor, erythroid 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NREP neuronal regeneration related protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFC platelet derived growth factor C
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PDZK1IP1 PDZK1 interacting protein 1
PIPOX pipecolic acid oxidase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SNX7 sorting nexin 7
SQLE squalene epoxidase
THY1 Thy-1 cell surface antigen
TMPO thymopoietin
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TST thiosulfate sulfurtransferase (rhodanese)
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
WDR7 WD repeat domain 7
WNT5A wingless-type MMTV integration site family, member 5A