BRD-U07805514_saracatinib_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-U07805514_saracatinib_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AKAP13 A kinase (PRKA) anchor protein 13
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARL4C ADP-ribosylation factor-like 4C
BAX BCL2-associated X protein
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL2A1 BCL2-related protein A1
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALB1 calbindin 1, 28kDa
CAPG capping protein (actin filament), gelsolin-like
CCDC92 coiled-coil domain containing 92
CD9 CD9 molecule
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COL6A1 collagen, type VI, alpha 1
CST1 cystatin SN
CTSA cathepsin A
CTSB cathepsin B
CTSL cathepsin L
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GM2A GM2 ganglioside activator
GNPDA1 glucosamine-6-phosphate deaminase 1
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
IDS iduronate 2-sulfatase
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IL13RA2 interleukin 13 receptor, alpha 2
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
LGALS3 lectin, galactoside-binding, soluble, 3
LPXN leupaxin
LYZ lysozyme
MACF1 microtubule-actin crosslinking factor 1
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MUC2 mucin 2, oligomeric mucus/gel-forming
NEFL neurofilament, light polypeptide
NPC1 Niemann-Pick disease, type C1
NUPL1 nucleoporin like 1
PCP4 Purkinje cell protein 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLIN2 perilipin 2
PLTP phospholipid transfer protein
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PRRC2C proline-rich coiled-coil 2C
PSIP1 PC4 and SFRS1 interacting protein 1
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REG1B regenerating islet-derived 1 beta
RGS1 regulator of G-protein signaling 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG9 sperm associated antigen 9
SPP1 secreted phosphoprotein 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM87A transmembrane protein 87A
TNC tenascin C
TOB1 transducer of ERBB2, 1
TPP1 tripeptidyl peptidase I
VAT1 vesicle amine transport 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
CCND3 cyclin D3
CD24 CD24 molecule
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CREB3L2 cAMP responsive element binding protein 3-like 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CYCS cytochrome c, somatic
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GCH1 GTP cyclohydrolase 1
GLI2 GLI family zinc finger 2
GOLGA8A golgin A8 family, member A
HACD1 3-hydroxyacyl-CoA dehydratase 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LEPR leptin receptor
MEF2C myocyte enhancer factor 2C
MYCBP MYC binding protein
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PDLIM1 PDZ and LIM domain 1
PLK1 polo-like kinase 1
PROM1 prominin 1
S100P S100 calcium binding protein P
SOX9 SRY (sex determining region Y)-box 9
SPTSSA serine palmitoyltransferase, small subunit A
TARBP1 TAR (HIV-1) RNA binding protein 1
TLE4 transducin-like enhancer of split 4
TMSB15A thymosin beta 15a
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TSPAN8 tetraspanin 8
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1