BRD-U07805514_saracatinib_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-U07805514_saracatinib_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASPN asporin
ASS1 argininosuccinate synthase 1
AZU1 azurocidin 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CAST calpastatin
CD36 CD36 molecule (thrombospondin receptor)
CD81 CD81 molecule
CDC42 cell division cycle 42
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CPT1A carnitine palmitoyltransferase 1A (liver)
ECHDC2 enoyl CoA hydratase domain containing 2
ELANE elastase, neutrophil expressed
FOLR1 folate receptor 1 (adult)
GPX4 glutathione peroxidase 4
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-DRA major histocompatibility complex, class II, DR alpha
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ISG15 ISG15 ubiquitin-like modifier
LGALS3 lectin, galactoside-binding, soluble, 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFSD10 major facilitator superfamily domain containing 10
MME membrane metallo-endopeptidase
MYOF myoferlin
NQO2 NAD(P)H dehydrogenase, quinone 2
PCDH7 protocadherin 7
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTGER3 prostaglandin E receptor 3 (subtype EP3)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
STAT1 signal transducer and activator of transcription 1, 91kDa
TRIM2 tripartite motif containing 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AREG amphiregulin
BEX4 brain expressed, X-linked 4
BZW2 basic leucine zipper and W2 domains 2
C2CD5 C2 calcium-dependent domain containing 5
CADM1 cell adhesion molecule 1
CD34 CD34 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
DLK1 delta-like 1 homolog (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
EFS embryonal Fyn-associated substrate
EIF5 eukaryotic translation initiation factor 5
FGG fibrinogen gamma chain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HBB hemoglobin, beta
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGFBP6 insulin-like growth factor binding protein 6
IL6ST interleukin 6 signal transducer
LAMB1 laminin, beta 1
MBNL2 muscleblind-like splicing regulator 2
MYO1D myosin ID
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAGL1 pleiomorphic adenoma gene-like 1
PRR7 proline rich 7 (synaptic)
RELN reelin
RHOB ras homolog family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TAGLN2 transgelin 2
TM4SF1 transmembrane 4 L six family member 1
VSIG4 V-set and immunoglobulin domain containing 4