BRD-U07805514_saracatinib_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-U07805514_saracatinib_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATF3 activating transcription factor 3
CD9 CD9 molecule
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
FXYD3 FXYD domain containing ion transport regulator 3
GPNMB glycoprotein (transmembrane) nmb
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BK histone cluster 1, H2bk
HIST3H2A histone cluster 3, H2a
HOOK2 hook microtubule-tethering protein 2
KIF5C kinesin family member 5C
KRT18 keratin 18, type I
MYO5C myosin VC
MYOF myoferlin
NEBL nebulette
NQO1 NAD(P)H dehydrogenase, quinone 1
PRDX2 peroxiredoxin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TSC22D1 TSC22 domain family, member 1
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AIF1 allograft inflammatory factor 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AUTS2 autism susceptibility candidate 2
BCHE butyrylcholinesterase
CD14 CD14 molecule
CORO1A coronin, actin binding protein, 1A
CRELD2 cysteine-rich with EGF-like domains 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSG cathepsin G
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL12 chemokine (C-X-C motif) ligand 12
DEPTOR DEP domain containing MTOR-interacting protein
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DPYSL3 dihydropyrimidinase-like 3
EDNRB endothelin receptor type B
FAM129A family with sequence similarity 129, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FSTL1 follistatin-like 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JCHAIN joining chain of multimeric IgA and IgM
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MEIS2 Meis homeobox 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RBP1 retinol binding protein 1, cellular
RNASE6 ribonuclease, RNase A family, k6
RUNX3 runt-related transcription factor 3
SELPLG selectin P ligand
SOX11 SRY (sex determining region Y)-box 11