BRD-U00779237_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

247 genes differentially expressed following the BRD-U00779237_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
CALD1 caldesmon 1
CCL20 chemokine (C-C motif) ligand 20
CECR1 cat eye syndrome chromosome region, candidate 1
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPM carboxypeptidase M
CTGF connective tissue growth factor
CTSK cathepsin K
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EPYC epiphycan
FABP1 fatty acid binding protein 1, liver
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FN1 fibronectin 1
GLUD2 glutamate dehydrogenase 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPG2 heparan sulfate proteoglycan 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
INSM1 insulinoma-associated 1
KIAA0226L KIAA0226-like
KIAA1462 KIAA1462
LUM lumican
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MSN moesin
MUC16 mucin 16, cell surface associated
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCOLCE procollagen C-endopeptidase enhancer
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDIA3 protein disulfide isomerase family A, member 3
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRAME preferentially expressed antigen in melanoma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCG2 secretogranin II
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT10 septin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SST somatostatin
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TSPAN7 tetraspanin 7
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIM1 absent in melanoma 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ASF1A anti-silencing function 1A histone chaperone
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BCAS2 breast carcinoma amplified sequence 2
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CSK c-src tyrosine kinase
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAAF2 dynein, axonemal, assembly factor 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPF2 D4, zinc and double PHD fingers family 2
E2F6 E2F transcription factor 6
EDRF1 erythroid differentiation regulatory factor 1
EIF5 eukaryotic translation initiation factor 5
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
FBXO34 F-box protein 34
FEM1B fem-1 homolog b (C. elegans)
FHL2 four and a half LIM domains 2
FOXA1 forkhead box A1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GEMIN4 gem (nuclear organelle) associated protein 4
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HAUS3 HAUS augmin-like complex, subunit 3
HN1 hematological and neurological expressed 1
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INSIG1 insulin induced gene 1
INTS5 integrator complex subunit 5
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANSL2 KAT8 regulatory NSL complex subunit 2
KAT6A K(lysine) acetyltransferase 6A
KATNA1 katanin p60 (ATPase containing) subunit A 1
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KIF2A kinesin heavy chain member 2A
KIN Kin17 DNA and RNA binding protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
KYNU kynureninase
MAPK6 mitogen-activated protein kinase 6
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
METTL18 methyltransferase like 18
MFSD5 major facilitator superfamily domain containing 5
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MTF2 metal response element binding transcription factor 2
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDCD2 programmed cell death 2
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSPC1 paraspeckle component 1
RABIF RAB interacting factor
RAE1 ribonucleic acid export 1
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RNF139 ring finger protein 139
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SEPHS1 selenophosphate synthetase 1
SESN1 sestrin 1
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
STIL SCL/TAL1 interrupting locus
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TDG thymine-DNA glycosylase
TEX10 testis expressed 10
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM11 transmembrane protein 11
TMEM243 transmembrane protein 243, mitochondrial
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TRAF4 TNF receptor-associated factor 4
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCPKMT valosin containing protein lysine (K) methyltransferase
XBP1 X-box binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZBTB1 zinc finger and BTB domain containing 1
ZNF14 zinc finger protein 14
ZNF146 zinc finger protein 146
ZNF410 zinc finger protein 410
ZNF443 zinc finger protein 443