BRD-U00779237_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-U00779237_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD24 CD24 molecule
CFB complement factor B
CFH complement factor H
CTSV cathepsin V
DHCR24 24-dehydrocholesterol reductase
EID1 EP300 interacting inhibitor of differentiation 1
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM107A family with sequence similarity 107, member A
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA1 gap junction protein, alpha 1, 43kDa
GM2A GM2 ganglioside activator
GPC4 glypican 4
GPM6A glycoprotein M6A
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2BD histone cluster 1, H2bd
IGFBP5 insulin-like growth factor binding protein 5
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDR kinase insert domain receptor
KIAA0226L KIAA0226-like
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MSR1 macrophage scavenger receptor 1
NAT8 N-acetyltransferase 8 (GCN5-related, putative)
NEBL nebulette
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OSBPL1A oxysterol binding protein-like 1A
P3H2 prolyl 3-hydroxylase 2
PCLO piccolo presynaptic cytomatrix protein
PLVAP plasmalemma vesicle associated protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
RABGAP1L RAB GTPase activating protein 1-like
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SNX10 sorting nexin 10
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC1 stanniocalcin 1
TCF4 transcription factor 4
TEK TEK tyrosine kinase, endothelial
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TXNIP thioredoxin interacting protein
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ASF1A anti-silencing function 1A histone chaperone
ATMIN ATM interactor
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
BTG1 B-cell translocation gene 1, anti-proliferative
CANT1 calcium activated nucleotidase 1
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM208B family with sequence similarity 208, member B
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GAS1 growth arrest-specific 1
GEMIN4 gem (nuclear organelle) associated protein 4
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL6R interleukin 6 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM5B lysine (K)-specific demethylase 5B
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIF2A kinesin heavy chain member 2A
KYNU kynureninase
MAK16 MAK16 homolog (S. cerevisiae)
MALT1 MALT1 paracaspase
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MED17 mediator complex subunit 17
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NOP16 NOP16 nucleolar protein
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PALB2 partner and localizer of BRCA2
PDCD2 programmed cell death 2
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIF peptidylprolyl isomerase F
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
RABIF RAB interacting factor
RBM15 RNA binding motif protein 15
RHOF ras homolog family member F (in filopodia)
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SFN stratifin
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX3 T-box 3
TCP1 t-complex 1
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIMP4 TIMP metallopeptidase inhibitor 4
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TRIM32 tripartite motif containing 32
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
USP1 ubiquitin specific peptidase 1
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZYX zyxin