BRD-U00779237_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

222 genes differentially expressed following the BRD-U00779237_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAMDEC1 ADAM-like, decysin 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
APLP1 amyloid beta (A4) precursor-like protein 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BACE2 beta-site APP-cleaving enzyme 2
BAG6 BCL2-associated athanogene 6
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD38 CD38 molecule
CD47 CD47 molecule
CFB complement factor B
CHGA chromogranin A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA1 chloride channel accessory 1
CLGN calmegin
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CPM carboxypeptidase M
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
EZR ezrin
FAR2 fatty acyl CoA reductase 2
FASN fatty acid synthase
FBLN1 fibulin 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GPM6A glycoprotein M6A
GYG2 glycogenin 2
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
IL1R1 interleukin 1 receptor, type I
KIAA0226L KIAA0226-like
LCN2 lipocalin 2
LGALS4 lectin, galactoside-binding, soluble, 4
LGALS9 lectin, galactoside-binding, soluble, 9
LUM lumican
MAOA monoamine oxidase A
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NMU neuromedin U
NUCB1 nucleobindin 1
OLFM4 olfactomedin 4
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PLAU plasminogen activator, urokinase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
RNF167 ring finger protein 167
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPINK1 serine peptidase inhibitor, Kazal type 1
STX1A syntaxin 1A (brain)
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TOM1L1 target of myb1 (chicken)-like 1
TPP1 tripeptidyl peptidase I
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOLD1 apolipoprotein L domain containing 1
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCR7 chemokine (C-C motif) receptor 7
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CRYAB crystallin, alpha B
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYTL1 cytokine-like 1
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
FBXO34 F-box protein 34
FEM1C fem-1 homolog c (C. elegans)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GSPT2 G1 to S phase transition 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGB2 high mobility group box 2
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IER3 immediate early response 3
IER5 immediate early response 5
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KAT6A K(lysine) acetyltransferase 6A
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KEAP1 kelch-like ECH-associated protein 1
KLF2 Kruppel-like factor 2
KLK10 kallikrein-related peptidase 10
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
MAPK6 mitogen-activated protein kinase 6
MED13 mediator complex subunit 13
MFSD5 major facilitator superfamily domain containing 5
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS2 mitochondrial ribosomal protein S2
MRPS30 mitochondrial ribosomal protein S30
MSH6 mutS homolog 6
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OSER1 oxidative stress responsive serine-rich 1
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PRPF4 pre-mRNA processing factor 4
RAB22A RAB22A, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RBMS1 RNA binding motif, single stranded interacting protein 1
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RNF139 ring finger protein 139
RPL36 ribosomal protein L36
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RYBP RING1 and YY1 binding protein
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SEC24B SEC24 family member B
SGK1 serum/glucocorticoid regulated kinase 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TP53BP2 tumor protein p53 binding protein 2
TRIM32 tripartite motif containing 32
TSPYL5 TSPY-like 5
UMPS uridine monophosphate synthetase
VCAN versican
WEE1 WEE1 G2 checkpoint kinase
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF22 zinc finger protein 22
ZNF586 zinc finger protein 586