BRD-U00779237_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-U00779237_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRA2 adhesion G protein-coupled receptor A2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ANXA4 annexin A4
AQP1 aquaporin 1 (Colton blood group)
BLNK B-cell linker
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CFB complement factor B
CFH complement factor H
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLIP3 CAP-GLY domain containing linker protein 3
CLU clusterin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
CST6 cystatin E/M
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPP4 dipeptidyl-peptidase 4
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
FGB fibrinogen beta chain
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
GSN gelsolin
HIST1H1C histone cluster 1, H1c
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
ISYNA1 inositol-3-phosphate synthase 1
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LDB2 LIM domain binding 2
MGP matrix Gla protein
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML3 olfactomedin-like 3
ORM1 orosomucoid 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TCF4 transcription factor 4
TDO2 tryptophan 2,3-dioxygenase
TNS1 tensin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AKAP8 A kinase (PRKA) anchor protein 8
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CALML5 calmodulin-like 5
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CNOT4 CCR4-NOT transcription complex, subunit 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM102A family with sequence similarity 102, member A
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
PDE4B phosphodiesterase 4B, cAMP-specific
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFB2M transcription factor B2, mitochondrial
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TUBB2B tubulin, beta 2B class IIb
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1