BRD-K99749624_linifanib_HME1_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K99749624_linifanib_HME1_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ANXA4 annexin A4
APOA1 apolipoprotein A-I
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
C7 complement component 7
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD36 CD36 molecule (thrombospondin receptor)
CD99 CD99 molecule
CDC42 cell division cycle 42
CFI complement factor I
CTSH cathepsin H
CXADR coxsackie virus and adenovirus receptor
DEFB1 defensin, beta 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPCAM epithelial cell adhesion molecule
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOXG1 forkhead box G1
FXYD2 FXYD domain containing ion transport regulator 2
GADD45B growth arrest and DNA-damage-inducible, beta
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
HAMP hepcidin antimicrobial peptide
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
KLF10 Kruppel-like factor 10
KRT8 keratin 8, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LEPROT leptin receptor overlapping transcript
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTA4H leukotriene A4 hydrolase
LYZ lysozyme
MAOB monoamine oxidase B
MEIS2 Meis homeobox 2
NFIL3 nuclear factor, interleukin 3 regulated
NMU neuromedin U
NREP neuronal regeneration related protein
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PEG10 paternally expressed 10
PHACTR2 phosphatase and actin regulator 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK2 polo-like kinase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRNP prion protein
RAB11FIP1 RAB11 family interacting protein 1 (class I)
REEP1 receptor accessory protein 1
S100A10 S100 calcium binding protein A10
SCG2 secretogranin II
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLIT2 slit homolog 2 (Drosophila)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
SYNGR1 synaptogyrin 1
TP53BP2 tumor protein p53 binding protein 2
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VCAN versican

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE41 basic helix-loop-helix family, member e41
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNF cyclin F
CD69 CD69 molecule
CD9 CD9 molecule
CDC25B cell division cycle 25B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL5A1 collagen, type V, alpha 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CST7 cystatin F (leukocystatin)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFHD2 EF-hand domain family, member D2
FASN fatty acid synthase
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FTH1 ferritin, heavy polypeptide 1
GPR137B G protein-coupled receptor 137B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGA2 high mobility group AT-hook 2
ICAM1 intercellular adhesion molecule 1
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAV integrin, alpha V
JADE2 jade family PHD finger 2
KCTD5 potassium channel tetramerization domain containing 5
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KYNU kynureninase
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LTF lactotransferrin
LYPD3 LY6/PLAUR domain containing 3
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
NKX3-1 NK3 homeobox 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
PBX3 pre-B-cell leukemia homeobox 3
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP prolactin-induced protein
POPDC3 popeye domain containing 3
POU2AF1 POU class 2 associating factor 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTGES prostaglandin E synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SFN stratifin
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNJ2 synaptojanin 2
TBX3 T-box 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
UST uronyl-2-sulfotransferase
ZMIZ1 zinc finger, MIZ-type containing 1