BRD-K99749624_linifanib_HME1_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K99749624_linifanib_HME1_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ARHGAP29 Rho GTPase activating protein 29
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX1 brain expressed, X-linked 1
BGN biglycan
BLNK B-cell linker
C7 complement component 7
CALD1 caldesmon 1
CCND2 cyclin D2
CD9 CD9 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLC Charcot-Leyden crystal galectin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CST1 cystatin SN
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DEGS1 delta(4)-desaturase, sphingolipid 1
DSC2 desmocollin 2
DSP desmoplakin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EDN1 endothelin 1
ERO1L ERO1-like (S. cerevisiae)
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLNA filamin A, alpha
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
HEBP2 heme binding protein 2
IFI27 interferon, alpha-inducible protein 27
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
ITGA8 integrin, alpha 8
JAG1 jagged 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIF5B kinesin family member 5B
KRT18 keratin 18, type I
LAMA3 laminin, alpha 3
LDHB lactate dehydrogenase B
MALL mal, T-cell differentiation protein-like
MGP matrix Gla protein
MX1 MX dynamin-like GTPase 1
MYL9 myosin, light chain 9, regulatory
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
P3H2 prolyl 3-hydroxylase 2
PAWR PRKC, apoptosis, WT1, regulator
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCCB propionyl CoA carboxylase, beta polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARD peroxisome proliferator-activated receptor delta
PRSS23 protease, serine, 23
QPCT glutaminyl-peptide cyclotransferase
RBM34 RNA binding motif protein 34
RGS5 regulator of G-protein signaling 5
RNASE3 ribonuclease, RNase A family, 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMS spermine synthase
SP110 SP110 nuclear body protein
SPAG4 sperm associated antigen 4
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFA transforming growth factor, alpha
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD10 ankyrin repeat domain 10
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCL6 B-cell CLL/lymphoma 6
C3 complement component 3
CKS2 CDC28 protein kinase regulatory subunit 2
CLGN calmegin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGR1 early growth response 1
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
FZD7 frizzled class receptor 7
GALE UDP-galactose-4-epimerase
IL1B interleukin 1, beta
IRS2 insulin receptor substrate 2
KLHDC2 kelch domain containing 2
KYNU kynureninase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MB myoglobin
METTL7A methyltransferase like 7A
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYOT myotilin
NEB nebulin
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
RDX radixin
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SOD2 superoxide dismutase 2, mitochondrial
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TFPI2 tissue factor pathway inhibitor 2
TTC39A tetratricopeptide repeat domain 39A
UBE2S ubiquitin-conjugating enzyme E2S