BRD-K99749624_linifanib_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K99749624_linifanib_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ACTA2 actin, alpha 2, smooth muscle, aorta
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX6 armadillo repeat containing, X-linked 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ASS1 argininosuccinate synthase 1
BEX1 brain expressed, X-linked 1
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CDC42 cell division cycle 42
CFLAR CASP8 and FADD-like apoptosis regulator
CLDN8 claudin 8
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5R2 cytochrome b5 reductase 2
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EDN1 endothelin 1
EFHD1 EF-hand domain family, member D1
EGF epidermal growth factor
EPCAM epithelial cell adhesion molecule
FGFR2 fibroblast growth factor receptor 2
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
GPX3 glutathione peroxidase 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HAL histidine ammonia-lyase
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MAPT microtubule-associated protein tau
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PADI2 peptidyl arginine deiminase, type II
PDLIM5 PDZ and LIM domain 5
PIP prolactin-induced protein
PROM1 prominin 1
PRSS8 protease, serine, 8
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB25 RAB25, member RAS oncogene family
RPP38 ribonuclease P/MRP 38kDa subunit
RRAGD Ras-related GTP binding D
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TACSTD2 tumor-associated calcium signal transducer 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TPM4 tropomyosin 4
TRAM1 translocation associated membrane protein 1
TTC39A tetratricopeptide repeat domain 39A
TUFT1 tuftelin 1
UMOD uromodulin
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADI1 acireductone dioxygenase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
ARL4C ADP-ribosylation factor-like 4C
CFB complement factor B
DPYD dihydropyrimidine dehydrogenase
EGR1 early growth response 1
ELOVL5 ELOVL fatty acid elongase 5
F5 coagulation factor V (proaccelerin, labile factor)
FLRT2 fibronectin leucine rich transmembrane protein 2
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
LXN latexin
MAP7 microtubule-associated protein 7
MMP9 matrix metallopeptidase 9
NELL2 NEL-like 2 (chicken)
SCG5 secretogranin V
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP4 TIMP metallopeptidase inhibitor 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase