BRD-K99633092_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-K99633092_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANKRD12 ankyrin repeat domain 12
ANXA3 annexin A3
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF7IP activating transcription factor 7 interacting protein
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CCNL1 cyclin L1
CDKN2AIP CDKN2A interacting protein
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
CNOT2 CCR4-NOT transcription complex, subunit 2
COL9A3 collagen, type IX, alpha 3
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
ELF1 E74-like factor 1 (ets domain transcription factor)
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GARS glycyl-tRNA synthetase
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
ING3 inhibitor of growth family, member 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INTS6 integrator complex subunit 6
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KYNU kynureninase
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MT1F metallothionein 1F
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
PER1 period circadian clock 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRRM2 serine/arginine repetitive matrix 2
SRSF7 serine/arginine-rich splicing factor 7
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSC22D3 TSC22 domain family, member 3
TTF1 transcription termination factor, RNA polymerase I
TUFT1 tuftelin 1
ZBTB20 zinc finger and BTB domain containing 20
ZCCHC8 zinc finger, CCHC domain containing 8
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF140 zinc finger protein 140
ZNF165 zinc finger protein 165
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AQP1 aquaporin 1 (Colton blood group)
B3GNT1
BCHE butyrylcholinesterase
CALD1 caldesmon 1
CD93 CD93 molecule
CLCA4 chloride channel accessory 4
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
COX11 COX11 cytochrome c oxidase copper chaperone
DHRS1 dehydrogenase/reductase (SDR family) member 1
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DUSP7 dual specificity phosphatase 7
EIF1AX eukaryotic translation initiation factor 1A, X-linked
ENO1 enolase 1, (alpha)
EPN2 epsin 2
FAM49A family with sequence similarity 49, member A
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GNPDA1 glucosamine-6-phosphate deaminase 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HTRA1 HtrA serine peptidase 1
KCTD12 potassium channel tetramerization domain containing 12
KRT6A keratin 6A, type II
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO3 LIM domain only 3 (rhombotin-like 2)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LY96 lymphocyte antigen 96
LYPD3 LY6/PLAUR domain containing 3
MALL mal, T-cell differentiation protein-like
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MME membrane metallo-endopeptidase
NMU neuromedin U
NT5DC2 5'-nucleotidase domain containing 2
PARP1 poly (ADP-ribose) polymerase 1
PCP4 Purkinje cell protein 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRDX4 peroxiredoxin 4
PRKCA protein kinase C, alpha
RPA1 replication protein A1, 70kDa
SDC1 syndecan 1
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
TM4SF1 transmembrane 4 L six family member 1
TM9SF2 transmembrane 9 superfamily member 2
TSPAN7 tetraspanin 7
TUBB tubulin, beta class I
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
ZNF589 zinc finger protein 589