BRD-K99633092_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

262 genes differentially expressed following the BRD-K99633092_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANKRD12 ankyrin repeat domain 12
ARC activity-regulated cytoskeleton-associated protein
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATF7IP activating transcription factor 7 interacting protein
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BCL3 B-cell CLL/lymphoma 3
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C21ORF91 chromosome 21 open reading frame 91
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTH cystathionine gamma-lyase
CYLD cylindromatosis (turban tumor syndrome)
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
H2BFS H2B histone family, member S (pseudogene)
HCFC2 host cell factor C2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
INTS6 integrator complex subunit 6
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LGALS3 lectin, galactoside-binding, soluble, 3
LTF lactotransferrin
LXN latexin
MAOB monoamine oxidase B
MCL1 myeloid cell leukemia 1
MEG3 maternally expressed 3 (non-protein coding)
MGP matrix Gla protein
MPO myeloperoxidase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PNP purine nucleoside phosphorylase
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SIK3 SIK family kinase 3
SNX11 sorting nexin 11
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
STAR steroidogenic acute regulatory protein
TBX2 T-box 2
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
TRIM13 tripartite motif containing 13
TTC39A tetratricopeptide repeat domain 39A
TXNL4B thioredoxin-like 4B
XBP1 X-box binding protein 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ADGRA3 adhesion G protein-coupled receptor A3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
APP amyloid beta (A4) precursor protein
ASPH aspartate beta-hydroxylase
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP9A ATPase, class II, type 9A
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CCNA2 cyclin A2
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CIRBP cold inducible RNA binding protein
CKB creatine kinase, brain
CLCA4 chloride channel accessory 4
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COX11 COX11 cytochrome c oxidase copper chaperone
DERA deoxyribose-phosphate aldolase (putative)
DPYSL2 dihydropyrimidinase-like 2
DUOX2 dual oxidase 2
ENO1 enolase 1, (alpha)
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM114A1 family with sequence similarity 114, member A1
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
GDE1 glycerophosphodiester phosphodiesterase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GREM1 gremlin 1, DAN family BMP antagonist
GSTP1 glutathione S-transferase pi 1
HAT1 histone acetyltransferase 1
HDAC2 histone deacetylase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
HMGN3 high mobility group nucleosomal binding domain 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM3 interferon induced transmembrane protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IPO5 importin 5
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAPTM4B lysosomal protein transmembrane 4 beta
LEPROTL1 leptin receptor overlapping transcript-like 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB2 lamin B2
LOX lysyl oxidase
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYPLA1 lysophospholipase I
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MPZL1 myelin protein zero-like 1
MSH6 mutS homolog 6
MTSS1 metastasis suppressor 1
MXRA7 matrix-remodelling associated 7
NDFIP1 Nedd4 family interacting protein 1
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NMU neuromedin U
NPC2 Niemann-Pick disease, type C2
NR2F6 nuclear receptor subfamily 2, group F, member 6
PA2G4 proliferation-associated 2G4, 38kDa
PARP1 poly (ADP-ribose) polymerase 1
PGAM1 phosphoglycerate mutase 1 (brain)
PPAP2C phosphatidic acid phosphatase type 2C
PRDX1 peroxiredoxin 1
PSCA prostate stem cell antigen
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PXDN peroxidasin
RAB2A RAB2A, member RAS oncogene family
RPA1 replication protein A1, 70kDa
SAMM50 SAMM50 sorting and assembly machinery component
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEC23A Sec23 homolog A (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNX6 sorting nexin 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF1 serine/arginine-rich splicing factor 1
STK24 serine/threonine kinase 24
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TM9SF2 transmembrane 9 superfamily member 2
TMEM14B transmembrane protein 14B
TNS3 tensin 3
TRAM1 translocation associated membrane protein 1
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VAMP3 vesicle-associated membrane protein 3
VDAC1 voltage-dependent anion channel 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VSNL1 visinin-like 1
WSB2 WD repeat and SOCS box containing 2