BRD-K99616396_S1032_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K99616396_S1032_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
APOD apolipoprotein D
AREG amphiregulin
ATF3 activating transcription factor 3
CD58 CD58 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHIC2 cysteine-rich hydrophobic domain 2
COL14A1 collagen, type XIV, alpha 1
CST3 cystatin C
CTGF connective tissue growth factor
CTSH cathepsin H
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
ELOVL5 ELOVL fatty acid elongase 5
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGF13 fibroblast growth factor 13
FMO2 flavin containing monooxygenase 2 (non-functional)
FOSL1 FOS-like antigen 1
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GPR137B G protein-coupled receptor 137B
HIGD1A HIG1 hypoxia inducible domain family, member 1A
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
LEF1 lymphoid enhancer-binding factor 1
LIF leukemia inhibitory factor
LTF lactotransferrin
MAP7 microtubule-associated protein 7
MBP myelin basic protein
MLPH melanophilin
MT1G metallothionein 1G
MT1X metallothionein 1X
MYH11 myosin, heavy chain 11, smooth muscle
MYO6 myosin VI
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP98 nucleoporin 98kDa
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
PMP22 peripheral myelin protein 22
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100A11 S100 calcium binding protein A11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TJP2 tight junction protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX3 TOX high mobility group box family member 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)

decreased expression

Symbol Name
BCAM basal cell adhesion molecule (Lutheran blood group)
CRABP2 cellular retinoic acid binding protein 2
FABP4 fatty acid binding protein 4, adipocyte
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LEPR leptin receptor
METTL7A methyltransferase like 7A
MFAP2 microfibrillar-associated protein 2
MME membrane metallo-endopeptidase
NARFL nuclear prelamin A recognition factor-like
NDFIP1 Nedd4 family interacting protein 1
NEB nebulin
OPN3 opsin 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKCA protein kinase C, alpha
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SOX11 SRY (sex determining region Y)-box 11
TCF4 transcription factor 4
TMEM30B transmembrane protein 30B
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN12 tetraspanin 12
ZNF395 zinc finger protein 395