BRD-K99582188_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

172 genes differentially expressed following the BRD-K99582188_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ANGPT2 angiopoietin 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BMP2 bone morphogenetic protein 2
CADM1 cell adhesion molecule 1
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM107A family with sequence similarity 107, member A
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FST follistatin
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GREM1 gremlin 1, DAN family BMP antagonist
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
INHBA inhibin, beta A
INHBB inhibin, beta B
IRF1 interferon regulatory factor 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KRT8 keratin 8, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MEIS2 Meis homeobox 2
MMP2 matrix metallopeptidase 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCLO piccolo presynaptic cytomatrix protein
PECAM1 platelet/endothelial cell adhesion molecule 1
PKP2 plakophilin 2
PLAU plasminogen activator, urokinase
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKCI protein kinase C, iota
PTPRC protein tyrosine phosphatase, receptor type, C
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RND3 Rho family GTPase 3
S100A8 S100 calcium binding protein A8
SCG5 secretogranin V
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI2 snail family zinc finger 2
SNX7 sorting nexin 7
SOCS2 suppressor of cytokine signaling 2
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
STK38L serine/threonine kinase 38 like
TCF4 transcription factor 4
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNF cyclin F
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
EBP emopamil binding protein (sterol isomerase)
ELOVL2 ELOVL fatty acid elongase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F5 coagulation factor V (proaccelerin, labile factor)
FGF13 fibroblast growth factor 13
GPER1 G protein-coupled estrogen receptor 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IL17RB interleukin 17 receptor B
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIF20A kinesin family member 20A
KLK11 kallikrein-related peptidase 11
KRT10 keratin 10, type I
LEPR leptin receptor
LOC440434 aminopeptidase puromycin sensitive pseudogene
LTF lactotransferrin
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAMLD1 mastermind-like domain containing 1
MPHOSPH9 M-phase phosphoprotein 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
OPN3 opsin 3
PARP2 poly (ADP-ribose) polymerase 2
PCTP phosphatidylcholine transfer protein
PDZK1 PDZ domain containing 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPA1 replication protein A1, 70kDa
SEC11A SEC11 homolog A (S. cerevisiae)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TLR4 toll-like receptor 4
TSPAN8 tetraspanin 8