BRD-K99545815_PF-562271_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K99545815_PF-562271_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
APLP2 amyloid beta (A4) precursor-like protein 2
C7 complement component 7
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
COL3A1 collagen, type III, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CST3 cystatin C
CSTA cystatin A (stefin A)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP1 epithelial membrane protein 1
GJA1 gap junction protein, alpha 1, 43kDa
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
KDM5D lysine (K)-specific demethylase 5D
KRT6A keratin 6A, type II
LRMP lymphoid-restricted membrane protein
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
PID1 phosphotyrosine interaction domain containing 1
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SYNE2 spectrin repeat containing, nuclear envelope 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMSB15A thymosin beta 15a
TSPAN7 tetraspanin 7
USP9Y ubiquitin specific peptidase 9, Y-linked
VWF von Willebrand factor

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
BASP1 brain abundant, membrane attached signal protein 1
CCNF cyclin F
CHD7 chromodomain helicase DNA binding protein 7
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL5A1 collagen, type V, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
ETV1 ets variant 1
FGF1 fibroblast growth factor 1 (acidic)
FZD2 frizzled class receptor 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KIAA1598
MBP myelin basic protein
MERTK MER proto-oncogene, tyrosine kinase
NAV3 neuron navigator 3
NOTCH1 notch 1
NUP62 nucleoporin 62kDa
OXTR oxytocin receptor
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
PLK2 polo-like kinase 2
PRKCA protein kinase C, alpha
RPP38 ribonuclease P/MRP 38kDa subunit
SCGB2A2 secretoglobin, family 2A, member 2
SMC1A structural maintenance of chromosomes 1A
SPINK1 serine peptidase inhibitor, Kazal type 1
TBC1D4 TBC1 domain family, member 4
TFF1 trefoil factor 1
TNS3 tensin 3