BRD-K99545815_HY-10459_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

329 genes differentially expressed following the BRD-K99545815_HY-10459_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
AGA aspartylglucosaminidase
ARG2 arginase 2
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BLNK B-cell linker
C3 complement component 3
C7 complement component 7
CADM1 cell adhesion molecule 1
CALD1 caldesmon 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CERS6 ceramide synthase 6
CHN2 chimerin 2
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
DDR2 discoidin domain receptor tyrosine kinase 2
EIF5A eukaryotic translation initiation factor 5A
EPYC epiphycan
FOLR1 folate receptor 1 (adult)
GJA1 gap junction protein, alpha 1, 43kDa
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL13RA2 interleukin 13 receptor, alpha 2
INA internexin neuronal intermediate filament protein, alpha
ISYNA1 inositol-3-phosphate synthase 1
KIAA0226L KIAA0226-like
KRT8 keratin 8, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTB lymphotoxin beta (TNF superfamily, member 3)
MAGEA3 melanoma antigen family A3
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MFAP2 microfibrillar-associated protein 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NTS neurotensin
PDLIM3 PDZ and LIM domain 3
PLS3 plastin 3
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCI protein kinase C, iota
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RNASE6 ribonuclease, RNase A family, k6
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SORT1 sortilin 1
STC1 stanniocalcin 1
TMSB15A thymosin beta 15a
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNNC1 troponin C type 1 (slow)
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3
VTCN1 V-set domain containing T cell activation inhibitor 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AQP3 aquaporin 3 (Gill blood group)
ARF6 ADP-ribosylation factor 6
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID1A AT rich interactive domain 1A (SWI-like)
ARL4A ADP-ribosylation factor-like 4A
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BASP1 brain abundant, membrane attached signal protein 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BIK BCL2-interacting killer (apoptosis-inducing)
BLCAP bladder cancer associated protein
BRD2 bromodomain containing 2
BRPF1 bromodomain and PHD finger containing, 1
BTG1 B-cell translocation gene 1, anti-proliferative
C14ORF169 chromosome 14 open reading frame 169
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD44 CD44 molecule (Indian blood group)
CD70 CD70 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CEP192 centrosomal protein 192kDa
CEP76 centrosomal protein 76kDa
CGRRF1 cell growth regulator with ring finger domain 1
CHD7 chromodomain helicase DNA binding protein 7
CHERP calcium homeostasis endoplasmic reticulum protein
CNOT4 CCR4-NOT transcription complex, subunit 4
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COIL coilin
CREBBP CREB binding protein
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DAXX death-domain associated protein
DBF4 DBF4 zinc finger
DCP1A decapping mRNA 1A
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP14 dual specificity phosphatase 14
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EFHD2 EF-hand domain family, member D2
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FADD Fas (TNFRSF6)-associated via death domain
FAM208B family with sequence similarity 208, member B
FAM222B family with sequence similarity 222, member B
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FBXO11 F-box protein 11
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GEMIN4 gem (nuclear organelle) associated protein 4
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPATCH8 G patch domain containing 8
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER1 homer scaffolding protein 1
HOXA10 homeobox A10
HOXA11 homeobox A11
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IL6R interleukin 6 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ING3 inhibitor of growth family, member 3
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
KANSL2 KAT8 regulatory NSL complex subunit 2
KAT6A K(lysine) acetyltransferase 6A
KDM2A lysine (K)-specific demethylase 2A
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
MKNK2 MAP kinase interacting serine/threonine kinase 2
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS2 mitochondrial ribosomal protein S2
MSH6 mutS homolog 6
MSL2 male-specific lethal 2 homolog (Drosophila)
MTPAP mitochondrial poly(A) polymerase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
NCALD neurocalcin delta
NET1 neuroepithelial cell transforming 1
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OSER1 oxidative stress responsive serine-rich 1
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PFKP phosphofructokinase, platelet
PHF20 PHD finger protein 20
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
PLK4 polo-like kinase 4
PNMA1 paraneoplastic Ma antigen 1
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAE1 ribonucleic acid export 1
RAP2B RAP2B, member of RAS oncogene family
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RNF139 ring finger protein 139
RNF19B ring finger protein 19B
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPP14 ribonuclease P/MRP 14kDa subunit
RPP38 ribonuclease P/MRP 38kDa subunit
RREB1 ras responsive element binding protein 1
RRP1B ribosomal RNA processing 1B
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SCGB2A2 secretoglobin, family 2A, member 2
SERTAD2 SERTA domain containing 2
SETD1B SET domain containing 1B
SETD5 SET domain containing 5
SFN stratifin
SIX2 SIX homeobox 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SNIP1 Smad nuclear interacting protein 1
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPATA2 spermatogenesis associated 2
SPRY2 sprouty homolog 2 (Drosophila)
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TACC3 transforming, acidic coiled-coil containing protein 3
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIM27 tripartite motif containing 27
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE3A ubiquitin protein ligase E3A
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VEZF1 vascular endothelial zinc finger 1
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC2 zinc finger, CCHC domain containing 2
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF12 zinc finger protein 12
ZNF131 zinc finger protein 131
ZNF200 zinc finger protein 200
ZNF22 zinc finger protein 22
ZNF263 zinc finger protein 263
ZNF281 zinc finger protein 281
ZNF443 zinc finger protein 443
ZNF473 zinc finger protein 473
ZNF574 zinc finger protein 574