BRD-K99530743_NCGC00242340-01_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K99530743_NCGC00242340-01_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD3 abhydrolase domain containing 3
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD12 ankyrin repeat domain 12
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BUD31 BUD31 homolog (S. cerevisiae)
CD24 CD24 molecule
CD9 CD9 molecule
CHGB chromogranin B
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
COL6A1 collagen, type VI, alpha 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EPAS1 endothelial PAS domain protein 1
FAM129A family with sequence similarity 129, member A
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
G6PD glucose-6-phosphate dehydrogenase
GABPB1 GA binding protein transcription factor, beta subunit 1
GCLM glutamate-cysteine ligase, modifier subunit
GNAS GNAS complex locus
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IL1R2 interleukin 1 receptor, type II
IL7R interleukin 7 receptor
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JUN jun proto-oncogene
LAMP1 lysosomal-associated membrane protein 1
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEFH neurofilament, heavy polypeptide
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PDLIM5 PDZ and LIM domain 5
PRNP prion protein
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RGS10 regulator of G-protein signaling 10
RHOF ras homolog family member F (in filopodia)
RND3 Rho family GTPase 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOWAHC sosondowah ankyrin repeat domain family member C
SPEN spen family transcriptional repressor
SPINK1 serine peptidase inhibitor, Kazal type 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC2 transforming, acidic coiled-coil containing protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UFM1 ubiquitin-fold modifier 1
WASL Wiskott-Aldrich syndrome-like
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ANXA6 annexin A6
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP5M1 adaptor-related protein complex 5, mu 1 subunit
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CDC20 cell division cycle 20
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CHRDL1 chordin-like 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
COG2 component of oligomeric golgi complex 2
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
GINS1 GINS complex subunit 1 (Psf1 homolog)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
HMGN3 high mobility group nucleosomal binding domain 3
IFITM2 interferon induced transmembrane protein 2
IL33 interleukin 33
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
LAP3 leucine aminopeptidase 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
PARP2 poly (ADP-ribose) polymerase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX2 peroxiredoxin 2
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PXDN peroxidasin
SELENBP1 selenium binding protein 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNS1 tensin 1
TSPAN12 tetraspanin 12
WT1 Wilms tumor 1