BRD-K99252563_QL-XII-47_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K99252563_QL-XII-47_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
CD34 CD34 molecule
CLC Charcot-Leyden crystal galectin
CRABP1 cellular retinoic acid binding protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
DLK1 delta-like 1 homolog (Drosophila)
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ESRP1 epithelial splicing regulatory protein 1
F11R F11 receptor
FRZB frizzled-related protein
FZD5 frizzled class receptor 5
H1F0 H1 histone family, member 0
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
JAG1 jagged 1
KAZN kazrin, periplakin interacting protein
LIMCH1 LIM and calponin homology domains 1
LPAR6 lysophosphatidic acid receptor 6
MCL1 myeloid cell leukemia 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOTCH1 notch 1
NPTX2 neuronal pentraxin II
PDGFD platelet derived growth factor D
PDIA3 protein disulfide isomerase family A, member 3
PRAME preferentially expressed antigen in melanoma
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD23B RAD23 homolog B (S. cerevisiae)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SCGB2A1 secretoglobin, family 2A, member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSPAN4 tetraspanin 4

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
AMACR alpha-methylacyl-CoA racemase
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BEX1 brain expressed, X-linked 1
CD44 CD44 molecule (Indian blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
FXYD5 FXYD domain containing ion transport regulator 5
HOMER1 homer scaffolding protein 1
HP haptoglobin
IRS2 insulin receptor substrate 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
PCP4 Purkinje cell protein 4
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PRKCA protein kinase C, alpha
PRR15L proline rich 15-like
PSD3 pleckstrin and Sec7 domain containing 3
PTN pleiotrophin
RAB31 RAB31, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX10 sorting nexin 10
STC1 stanniocalcin 1
TSPAN8 tetraspanin 8
VAV3 vav 3 guanine nucleotide exchange factor